4-Hydroxycinnamate Lowers Plasma and Hepatic Lipids without Changing Antioxidant Enzyme Activities
Background/Aims: The purpose of this study was to investigate the influence of 4-hydroxycinnamate (4-(OH)-C) supplement on the lipid metabolism and antioxidant system of rats fed a high-cholesterol diet. Methods: Three groups of rats were given a diet containing 1 g cholesterol/kg for 6 weeks. The c...
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Published in | Annals of nutrition and metabolism Vol. 47; no. 3; pp. 144 - 151 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Basel, Switzerland
S. Karger AG
2003
Karger |
Subjects | |
Online Access | Get full text |
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Summary: | Background/Aims: The purpose of this study was to investigate the influence of 4-hydroxycinnamate (4-(OH)-C) supplement on the lipid metabolism and antioxidant system of rats fed a high-cholesterol diet. Methods: Three groups of rats were given a diet containing 1 g cholesterol/kg for 6 weeks. The control group only received a high cholesterol diet, whereas the other two groups received a diet including lovastatin or 4-(OH)-C (0.1 g/100 g). Results: The plasma total cholesterol concentration was significantly lowered by the 4-(OH)-C supplement, whereas the HDL-cholesterol level was higher in this group. The 4-(OH)-C supplement significantly lowered the hepatic cholesterol and triglycerides levels, respectively. Accumulation of hepatic lipid droplet was the highest in control group; however, it was decreased by supplementation of the 4-(OH)-C and the lovastatin. The hepatic HMG-CoA reductase activities were not significantly different between the groups, whereas the ACAT activity was significantly lowered in the lovastatin group. The 4-(OH)-C significantly lowered the hepatic TBARS content. And it did not alter the neutral sterol and total fecal sterol, however, the fecal acidic sterol was higher in the lovastatin and the 4-(OH)-C groups than in the control group. Conclusion: These results indicate that 4-(OH)-C was effective in lowering the plasma cholesterol and hepatic lipids. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0250-6807 1421-9697 |
DOI: | 10.1159/000070037 |