Hemodynamic forces using four-dimensional flow MRI: an independent biomarker of cardiac function in heart failure with left ventricular dyssynchrony?

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 315; no. 6; pp. H1627 - H1639
• Main Authors: Arvidsson, Per M., Töger, Johannes, Pedrizzetti, Gianni, Heiberg, Einar, Borgquist, Rasmus, Carlsson, Marcus, Arheden, Håkan
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2018
• Subjects: Aged; Aged, 80 and over; Aortic valve; Biomarkers; Cardiac and Cardiovascular Systems; Cardiac function; Cardiology and Cardiovascular Disease; Clinical Medicine; Computational fluid dynamics; Correlation analysis; Diastole; Dyssynchrony; Female; Four-dimensional flow; Heart; Heart diseases; Heart failure; Heart Failure - diagnostic imaging; Heart Failure - physiopathology; Hemodynamic force; Hemodynamics; Humans; Implantation; Kardiologi; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Middle Aged; Myocardial Perfusion Imaging - methods; NMR; Nuclear magnetic resonance; Patients; Physiology; Risk analysis; Systole; Ventricle; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; physiology; heart failure; dyssynchrony; hemodynamic force; four-dimensional flow

Patients with heart failure with left ventricular (LV) dyssynchrony often do not respond to cardiac resynchronization therapy (CRT), indicating that the pathophysiology is insufficiently understood. Intracardiac hemodynamic forces computed from four-dimensional (4-D) flow MRI have been proposed as a...