Fluoroquinolone Antimicrobials: Singlet Oxygen, Superoxide and Phototoxicity

• Published in: Photochemistry and photobiology Vol. 67; no. 4; pp. 399 - 403
• Main Authors: Martinez, Lydia J., Sik, Robert H., Chignell, Colin F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.1998
• Subjects: Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - toxicity; Fluoroquinolones; Free Radicals; Guinea Pigs; Humans; Hydroxyl Radical; Mice; Oxygen; Photosensitizing Agents - chemistry; Photosensitizing Agents - toxicity; Quinolones - chemistry; Quinolones - toxicity; Salmonella typhimurium - drug effects; Singlet Oxygen; Structure-Activity Relationship; Superoxides

ABSTRACT The fluoroquinolone antibacterial agents possess photo‐sensitizing properties that lead to phototoxic responses in both human and animal subjects. The phototoxicity order reported in humans is: fleroxacin > lomefloxacin, pefloxacin > ciprofloxacin ≫ enoxacin, norfloxacin and ofloxacin...