Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects

• Published in: Neurology : neuroimmunology & neuroinflammation Vol. 8; no. 1; p. e916
• Main Authors: Landa, Jon, Guasp, Mar, Petit-Pedrol, Mar, Martínez-Hernández, Eugenia, Planagumà, Jesús, Saiz, Albert, Ruiz-García, Raquel, García-Fernández, Lorena, Verschuuren, Jan, Saunders-Pullman, Rachel, Ramirez-Gómez, Liliana, Geschwind, Michael D., Dalmau, Josep, Sabater, Lidia, Graus, Francesc
• Format: Journal Article
• Language: English
• Published: United States American Academy of Neurology 01.01.2021; Lippincott Williams & Wilkins
• Subjects: Aged; Animals; Autoantibodies - immunology; Autoimmunity - immunology; Cerebellar Ataxia - immunology; Female; Humans; Male; Middle Aged; Rats
• ISSN: 2332-7812; 2332-7812
• DOI: 10.1212/NXI.0000000000000916

To describe the clinical syndrome of 4 new patients with seizure-related 6 homolog like 2 antibodies (SEZ6L2-abs), study the antibody characteristics, and evaluate their effects on neuronal cultures. SEZ6L2-abs were initially identified in serum and CSF of a patient with cerebellar ataxia by immunoh...