Calcitonin gene-related peptide in patients with endocrine tumors

The plasma level of calcitonin gene-related peptide (CGRP) was measured by RIA in 41 patients with endocrine tumors [22 medullary thyroid carcinomas (MTC), seven parathyroid adenomas, four benign insulinomas, five carcinoids, and three pheochromocytomas]. Of the 22 patients with MTC, all five preope...

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Bibliographic Details
Published inJournal of surgical oncology Vol. 43; no. 1; p. 28
Main Authors Takami, H, Shikata, J, Kakudo, K, Ito, K
Format Journal Article
LanguageEnglish
Published United States 01.01.1990
Subjects
Adenoma - blood
Adrenal Gland Neoplasms - blood
Calcitonin - blood
Calcitonin Gene-Related Peptide - blood
Carcinoid Tumor - blood
Endocrine System Diseases - blood
Humans
Immunohistochemistry
Insulinoma - blood
Neoplasms - blood
Pancreatic Neoplasms - blood
Parathyroid Neoplasms - blood
Pheochromocytoma - blood
Radioimmunoassay
Thyroid Neoplasms - blood
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Summary:The plasma level of calcitonin gene-related peptide (CGRP) was measured by RIA in 41 patients with endocrine tumors [22 medullary thyroid carcinomas (MTC), seven parathyroid adenomas, four benign insulinomas, five carcinoids, and three pheochromocytomas]. Of the 22 patients with MTC, all five preoperative patients had elevated CGRP levels. The correlation between CGRP and calcitonin levels was significant (P less than .001) in 22 patients with MTC. Six of 19 patients with endocrine tumors other than MTC showed elevated CGRP levels. Immunohistochemical study showed that tumor tissues from all 22 cases of MTC and seven from other endocrine tumors contained immunoreactive CGRP. CGRP reactivity was found in only small numbers of tumor cells. Thus, although CGRP appeared to be a useful additional marker for MTC, the role of CGRP in the pathophysiology of endocrine tumors was not elucidated.
ISSN:0022-4790
DOI:10.1002/jso.2930430108