Clinicopathologic and Genetic Features of Primary T-cell Lymphomas of the Central Nervous System: An Analysis of 11 Cases Using Targeted Gene Sequencing

• Published in: The American journal of surgical pathology Vol. 46; no. 4; p. 486
• Main Authors: Yim, Jeemin, Koh, Jiwon, Kim, Sehui, Song, Seung Geun, Bae, Jeong Mo, Yun, Hongseok, Sung, Ji-Youn, Kim, Tae Min, Park, Sung-Hye, Jeon, Yoon Kyung
• Format: Journal Article
• Language: English
• Published: United States 01.04.2022
• Subjects: Adolescent; Adult; Aged; Anaplastic Lymphoma Kinase - metabolism; Central Nervous System Neoplasms - genetics; Central Nervous System Neoplasms - metabolism; Central Nervous System Neoplasms - pathology; Child; Child, Preschool; Female; Humans; Lymphoma, Extranodal NK-T-Cell - genetics; Lymphoma, Extranodal NK-T-Cell - metabolism; Lymphoma, Extranodal NK-T-Cell - pathology; Lymphoma, Large-Cell, Anaplastic - genetics; Lymphoma, Large-Cell, Anaplastic - metabolism; Lymphoma, Large-Cell, Anaplastic - pathology; Lymphoma, T-Cell, Peripheral - genetics; Lymphoma, T-Cell, Peripheral - metabolism; Lymphoma, T-Cell, Peripheral - pathology; Male; Middle Aged; Young Adult

Primary central nervous system lymphoma (PCNSL) of peripheral T-cell lineage (T-PCNSL) is rare, and its genetic and clinicopathologic features remain unclear. Here, we present 11 cases of T-PCNSL in immunocompetent individuals from a single institute, focusing on their genetic alterations. Seven cas...