Expression of Bcl-2 in human breast cancer: Correlation between hormone receptor status, p53 protein accumulation and DNA strand breaks associated with apoptosis

• Published in: Pathology international Vol. 47; no. 11; pp. 757 - 762
• Main Authors: Hori, Masao, Nogami, Tatsuya, Itabashi, Masayuki, Yoshimi, Fuyo, Ono, Hisayuki, Koizumi, Sumihiko
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.1997
• Subjects: Apoptosis; Bcl-2; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; DNA Damage; Female; hormone receptors; human breast cancer; Humans; Immunohistochemistry; p53 oncoprotein; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2 - metabolism; Receptors, Estrogen - metabolism; Receptors, Progesterone - metabolism; RNA, Messenger - analysis; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 - metabolism

The expression of Bcl‐2, a suppressor of apoptotic cell death, was Investigated in 52 invaslve carcinomas of the breast using reverse transcription‐polymerase chain reaction and Immunohistochemical methods. After consideration of both sets of results, 42 tumors (80.8%) were confirmed to be positive...