The Use of Real-Time Quantitative PCR to Detect Circulating Prostate-Specific Membrane Antigen mRNA in Patients with Prostate Carcinoma

• Published in: Annals of the New York Academy of Sciences Vol. 1022; no. 1; pp. 157 - 162
• Main Authors: CHU, DA-CHANG, CHUANG, CHENG-KENG, LIOU, YI-FANG, TZOU, RON-DAR, LEE, HSIAO-CHUN, SUN, CHIEN-FENG
• Format: Journal Article Book Chapter
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2004
• Subjects: Antigens, Surface - blood; Antigens, Surface - genetics; Biomarkers, Tumor - blood; Carcinoma - diagnosis; Cell Line, Tumor; Glutamate Carboxypeptidase II - blood; Glutamate Carboxypeptidase II - genetics; Humans; Male; nested PCR; noninvasive molecular diagnosis; Polymerase Chain Reaction; prostate cancer; prostate-specific membrane antigen (PSM); Prostatic Hyperplasia - diagnosis; Prostatic Neoplasms - diagnosis; real-time quantitative PCR; RNA, Messenger - blood; RNA, Messenger - genetics; Sensitivity and Specificity

: Prostate‐specific antigen (PSA) has long been criticized for its lack of specificity in screening for the occurrence of prostate cancer. In this study, we tried to measure levels of another biomarker, prostate‐specific membrane antigen (PSM), in the peripheral circulation from subjects with either...