Pharmacokinetic studies on atropine with special reference to age

• Published in: Acta anaesthesiologica Scandinavica Vol. 26; no. 4; p. 297
• Main Authors: Virtanen, R, Kanto, J, Iisalo, E, Iisalo, E U, Salo, M, Sjövall, S
• Format: Journal Article
• Language: English
• Published: England 01.08.1982
• Subjects: Adolescent; Adult; Aged; Aging; Atropine - metabolism; Atropine - pharmacology; Child; Child, Preschool; Female; Half-Life; Hemodynamics - drug effects; Humans; Infant; Injections, Intravenous; Kinetics; Male; Middle Aged; Time Factors

Pharmacokinetic studies on atropine were performed in 52 patients under general or spinal anaesthesia. Age had a clinically significant effect on the kinetics of this alkaloid: in children under 2 years of age and in the elderly a prolonged elimination was found. This might explain, partly at least,...