Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1-dimethylhydrazine, in a medium-term bioassay

• Published in: Teratogenesis, carcinogenesis, and mutagenesis Vol. 15; no. 6; p. 307
• Main Authors: Cabral, R, Hakoi, K, Hoshiya, T, Hasegawa, R, Ito, N
• Format: Journal Article
• Language: English
• Published: United States 1995
• Subjects: Adjuvants, Immunologic - toxicity; Animals; Biomarkers, Tumor - analysis; Carcinogenicity Tests; Carcinogens - toxicity; Diethylnitrosamine - toxicity; Dimethylhydrazines - toxicity; Drug Interactions; Glutathione Transferase - analysis; Herbicides - toxicity; Isoenzymes - analysis; Liver - drug effects; Liver - enzymology; Liver - pathology; Liver Neoplasms, Experimental - chemically induced; Liver Neoplasms, Experimental - enzymology; Liver Neoplasms, Experimental - pathology; Male; Plant Growth Regulators - toxicity; Precancerous Conditions - chemically induced; Precancerous Conditions - enzymology; Precancerous Conditions - pathology; Rats; Rats, Inbred F344; Succinates - toxicity

The carcinogenicity of daminozide (succinic acid-2,2-dimethylhydrazide; Alar), a plant growth regulator used primarily in apple orchards, has been the subject of recent investigations by several national and international organizations because of contradictory study results. The aim of the present s...