Remodelling of resistance arteries in genetically hypertensive rats by treatment with valsartan, an angiotensin II receptor antagonist

• Published in: Clinical and experimental pharmacology & physiology Vol. 23; no. 6-7; p. 576
• Main Authors: Ledingham, J M, Laverty, R
• Format: Journal Article
• Language: English
• Published: Australia 01.07.1996
• Subjects: Angiotensin II - metabolism; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Animals; Arteries - drug effects; Arteries - pathology; Blood Pressure - drug effects; Cardiomegaly - pathology; Hypertension - drug therapy; Hypertension - genetics; Hypertension - pathology; Male; Neovascularization, Pathologic - pathology; Rats; Rats, Inbred Strains; Receptors, Angiotensin - metabolism; Splanchnic Circulation - drug effects; Tetrazoles - therapeutic use; Valine - analogs & derivatives; Valine - therapeutic use; Valsartan; Vascular Resistance - drug effects

1. In the present study, New Zealand genetically hypertensive (GH) rats were treated with valsartan, a specific angiotensin II (AT1) receptor antagonist, to measure the effects on blood pressure (BP), cardiac hypertrophy and the structure of resistance arteries. Normotensive (N) rats were used as co...