Quantitative tissue sodium concentration mapping of normal rat brain

• Published in: Magnetic resonance in medicine Vol. 36; no. 1; p. 83
• Main Authors: Christensen, J D, Barrère, B J, Boada, F E, Vevea, J M, Thulborn, K R
• Format: Journal Article
• Language: English
• Published: United States 01.07.1996
• Subjects: Animals; Brain - diagnostic imaging; Brain - metabolism; Calibration; Hydrogen; Image Enhancement; Image Processing, Computer-Assisted; Indicator Dilution Techniques; Linear Models; Magnetic Resonance Imaging; Organ Size; Phantoms, Imaging; Radionuclide Imaging; Rats; Rats, Inbred F344; Sensitivity and Specificity; Sodium - metabolism; Sodium Isotopes; Sodium Radioisotopes

A quantitative in vivo method for obtaining maps of tissue sodium concentration (TSC) by MRI is compared to the invasive, global 22Na radionuclide dilutional technique in the normal rat brain. The MR method uses a three-dimensional projectional acquisition scheme to minimize signal losses from trans...