Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects

• Published in: Journal of proteomics Vol. 217; p. 103645
• Main Authors: Mindikoglu, Ayse L., Abdulsada, Mustafa M., Jain, Antrix, Choi, Jong Min, Jalal, Prasun K., Devaraj, Sridevi, Mezzari, Melissa P., Petrosino, Joseph F., Opekun, Antone R., Jung, Sung Yun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.04.2020
• Subjects: Alzheimer disease; animal models; blood serum; circadian clocks; cognition; cytoskeleton; diabetes; DNA repair; fasting; gene expression regulation; glucose; humans; immune system; inflammation; insulin; lipid metabolism; low calorie diet; metabolic syndrome; neoplasms; obesity; proteome; proteomics; regulatory proteins; tandem mass spectrometry; therapeutics; ultra-performance liquid chromatography; weight loss

Murine studies showed that disruption of circadian clock rhythmicity could lead to cancer and metabolic syndrome. Time-restricted feeding can reset the disrupted clock rhythm, protect against cancer and metabolic syndrome. Based on these observations, we hypothesized that intermittent fasting for se...