Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease

• Published in: International journal of immunogenetics Vol. 39; no. 3; pp. 247 - 252
• Main Authors: Polgar, N., Csongei, V., Szabo, M., Zambo, V., Melegh, B. I., Sumegi, K., Nagy, G., Tulassay, Z., Melegh, B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2012
• Subjects: Adult; Colitis, Ulcerative - genetics; Crohn Disease - genetics; Epistasis, Genetic; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Genotype; Humans; Hungary; Inflammatory Bowel Diseases - genetics; Janus Kinase 2 - genetics; Logistic Models; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptors, CCR6 - genetics; STAT3 Transcription Factor - genetics; Hungary

Summary Genome‐wide association studies identified many loci associated with the two forms of inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC). Components of the interleukin‐23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases....