Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation (PROACTIVE): An Open-Label Randomized Controlled Trial - Downar, James; Lapenskie, Julie; Kanji, Salmaan; Watpool, Irene; Haines, Jessica; Saeed, Uzma; Porteous, Rebecca; Polskaia, Nadia; Burry, Lisa; Himed, Shuhira; Anderson, Koby; Fox-Robichaud, Alison (Critical care medicine, 2025)
Keywords: Adult; Aged; Anti-Anxiety Agents - administration & dosage; Anti-Anxiety Agents - therapeutic use; COVID-19 - therapy; Critical Illness - therapy; Female; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - therapeutic use; Male; Midazolam - administration & dosage; Midazolam - therapeutic use; Middle Aged; Propofol - administration & dosage; Propofol - therapeutic use; Propranolol - administration & dosage; Propranolol - therapeutic use; Respiration, Artificial - methods