Auditory Brainstem Response Altered in Humans With Noise Exposure Despite Normal Outer Hair Cell Function

• Published in: Ear and hearing Vol. 38; no. 1; p. e1
• Main Authors: Bramhall, Naomi F, Konrad-Martin, Dawn, McMillan, Garnett P, Griest, Susan E
• Format: Journal Article
• Language: English
• Published: United States 01.01.2017
• Subjects: Adult; Audiometry, Pure-Tone; Auditory Threshold; Case-Control Studies; Evoked Potentials, Auditory, Brain Stem - physiology; Female; Hair Cells, Auditory, Outer - physiology; Hearing Loss, Noise-Induced - physiopathology; Humans; Male; Noise; Otoacoustic Emissions, Spontaneous; Vestibulocochlear Nerve Diseases - physiopathology; Veterans; Young Adult

Recent animal studies demonstrated that cochlear synaptopathy, a partial loss of inner hair cell-auditory nerve fiber synapses, can occur in response to noise exposure without any permanent auditory threshold shift. In animal models, this synaptopathy is associated with a reduction in the amplitude...