Liquid chromatography in pharmaceutical analysis VI: determination of dantrolene sodium in a dosage form
Operating conditions are described for the qualitative and quantitative determination of dantrolene sodium by high-pressure liquid chromatography. A 10-mum porous silica column was employed, using carbon tetrachloride-dimethylformamide (90:10) as the mobile phase. The flow rate was 2.0 ml/min (1800...
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Published in | Journal of pharmaceutical sciences Vol. 66; no. 2; p. 286 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.1977
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Abstract | Operating conditions are described for the qualitative and quantitative determination of dantrolene sodium by high-pressure liquid chromatography. A 10-mum porous silica column was employed, using carbon tetrachloride-dimethylformamide (90:10) as the mobile phase. The flow rate was 2.0 ml/min (1800 psig), and the peaks were detected at 375 nm. The analysis of a dosage form can be carried out within 30 min with an accuracy of 3.1%. The results agree favorably with those obtained with a modified spectrophotofluorometric method. |
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AbstractList | Operating conditions are described for the qualitative and quantitative determination of dantrolene sodium by high-pressure liquid chromatography. A 10-mum porous silica column was employed, using carbon tetrachloride-dimethylformamide (90:10) as the mobile phase. The flow rate was 2.0 ml/min (1800 psig), and the peaks were detected at 375 nm. The analysis of a dosage form can be carried out within 30 min with an accuracy of 3.1%. The results agree favorably with those obtained with a modified spectrophotofluorometric method. |
Author | Saxena, S J Honigberg, I L Vallner, J J Stewart, J T Keene, G R |
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SubjectTerms | Capsules - analysis Chromatography, High Pressure Liquid Dantrolene - analysis Hydantoins - analysis Spectrometry, Fluorescence |
Title | Liquid chromatography in pharmaceutical analysis VI: determination of dantrolene sodium in a dosage form |
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