Liquid chromatography in pharmaceutical analysis VI: determination of dantrolene sodium in a dosage form

Operating conditions are described for the qualitative and quantitative determination of dantrolene sodium by high-pressure liquid chromatography. A 10-mum porous silica column was employed, using carbon tetrachloride-dimethylformamide (90:10) as the mobile phase. The flow rate was 2.0 ml/min (1800...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 66; no. 2; p. 286
Main Authors Saxena, S J, Honigberg, I L, Stewart, J T, Keene, G R, Vallner, J J
Format Journal Article
LanguageEnglish
Published United States 01.02.1977
Subjects
Capsules - analysis
Chromatography, High Pressure Liquid
Dantrolene - analysis
Hydantoins - analysis
Spectrometry, Fluorescence
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Summary:Operating conditions are described for the qualitative and quantitative determination of dantrolene sodium by high-pressure liquid chromatography. A 10-mum porous silica column was employed, using carbon tetrachloride-dimethylformamide (90:10) as the mobile phase. The flow rate was 2.0 ml/min (1800 psig), and the peaks were detected at 375 nm. The analysis of a dosage form can be carried out within 30 min with an accuracy of 3.1%. The results agree favorably with those obtained with a modified spectrophotofluorometric method.
ISSN:0022-3549
DOI:10.1002/jps.2600660243