The metabolism of floctafenin in man and rodents

• Published in: Journal of clinical pharmacology Vol. 19; no. 1; p. 20
• Main Authors: Lynn, R K, Holm, R, Swanson, B N, Smith, R, Gerber, N
• Format: Journal Article
• Language: English
• Published: England 01.01.1979
• Subjects: Adult; Animals; Biotransformation; Half-Life; Humans; Hydroxylation; In Vitro Techniques; Male; Mice; ortho-Aminobenzoates - blood; ortho-Aminobenzoates - metabolism; ortho-Aminobenzoates - urine; Rats; Time Factors

Floctafenin (FFn), 2,3-dihydroxypropyl--N--(8--trifluoromethyl--4--quinolyl) anthranilate, a new nonnarcotic analgesic drug, was studied in man, mice, and the isolated perfused rat liver. In all species the drug is rapidly hydrolyzed to floctafenic acid (FFa). In seven volunteer subjects who each re...