Alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism
The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the...
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| Published in | Clinical endocrinology (Oxford) Vol. 14; no. 2; p. 113 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.02.1981
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| Subjects | |
| Online Access | Get more information |
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| Abstract | The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We suggest that the fall in the level of circulating thyroxine-binding globulin is related to a defect in its synthesis or secretion by the liver due to ethanol consumption. Caution is recommended in the interpretation of thyroid function tests in chronic alcoholics. |
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| AbstractList | The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We suggest that the fall in the level of circulating thyroxine-binding globulin is related to a defect in its synthesis or secretion by the liver due to ethanol consumption. Caution is recommended in the interpretation of thyroid function tests in chronic alcoholics. |
| Author | Prigogine, T Demeester-Mirkine, N Fernandez-Deville, M Glinoer, D Geurts, J Corvilain, J |
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| Snippet | The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in... |
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| SubjectTerms | Adult Alcoholism - blood Female Humans Male Middle Aged Thyroid Function Tests Thyroxine - blood Thyroxine-Binding Proteins - blood Triiodothyronine - blood |
| Title | Alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism |
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