Inhibitory effects of a bacteria-derived sulfated polysaccharide against basic fibroblast growth factor-induced endothelial cell growth and chemotaxis

• Published in: Journal of cellular physiology Vol. 154; no. 1; p. 1
• Main Authors: Nakayama, Y, Iwahana, M, Sakamoto, N, Tanaka, N G, Osada, Y
• Format: Journal Article
• Language: English
• Published: United States 01.01.1993
• Subjects: Cell Division - drug effects; Cells, Cultured; Chemotaxis - drug effects; Endothelium, Vascular - cytology; Epidermal Growth Factor - metabolism; Epidermal Growth Factor - physiology; Fibroblast Growth Factor 2 - antagonists & inhibitors; Fibroblast Growth Factor 2 - physiology; Humans; Kinetics; Polysaccharides, Bacterial - metabolism; Polysaccharides, Bacterial - pharmacology

The effects of sulfated polysaccharides on the growth and chemotaxis of endothelial cells promoted by basic fibroblast growth factor (bFGF), a heparin-binding growth factor, and epidermal growth factor (EGF), a non-heparin-binding growth factor, were examined. The binding abilities of these two grow...