The pharmacokinetics of oxytetracycline following intravenous administration in healthy and diseased pigs

• Published in: Journal of veterinary pharmacology and therapeutics Vol. 13; no. 3; p. 320
• Main Authors: Pijpers, A, Schoevers, E J, van Gogh, H, van Leengoed, L A, Visser, I J, van Miert, A S, Verheijden, J H
• Format: Journal Article
• Language: English
• Published: England 01.09.1990
• Subjects: Actinobacillus Infections - metabolism; Actinobacillus Infections - veterinary; Animals; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous - veterinary; Male; Oxytetracycline - administration & dosage; Oxytetracycline - pharmacokinetics; Oxytetracycline - urine; Pneumonia - metabolism; Pneumonia - veterinary; Swine - metabolism; Swine Diseases - metabolism; Tissue Distribution
• ISSN: 0140-7783
• DOI: 10.1111/j.1365-2885.1990.tb00783.x

The pharmacokinetics of oxytetracycline (OTC) were studied in healthy pigs and in pigs endobronchially inoculated with Actinobacillus pleuropneumoniae toxins. In two groups of seven pigs OTC was administered intravenously in a single dose of 10 or 50 mg/kg, respectively. OTC was administered to clinically healthy pigs and 7 days later at 3 h after a challenge with A. pleuropneumoniae toxins. Pneumonia developed in toxin-treated pigs. In the challenged pigs there was a decreased distribution-rate constant (alpha) and a significantly increased elimination-rate constant (beta) (P less than 0.05). Moreover, the apparent volume of distribution (Vd beta) was decreased. The elimination half-lives (t1/2 beta) were approximately 6 h in the healthy pigs and 5 h in the diseased animals. There was no difference in the pharmacokinetic profile of OTC following administration of 50 mg/kg compared to 10 mg/kg.