Impaired Macroscopic Cerebrospinal Fluid Flow by Sevoflurane in Humans during and after Anesthesia

• Published in: Anesthesiology (Philadelphia) Vol. 142; no. 4; pp. 692 - 703
• Main Authors: Zimmermann, Juliana, Sorg, Christian, Müller, Leander, Zistler, Franziska, Neumaier, Viktor, Bonhoeffer, Moritz, Ranft, Andreas, Golkowski, Daniel, Priller, Josef, Zimmer, Claus, Ilg, Rüdiger, Preibisch, Christine, Schneider, Gerhard, Nuttall, Rachel, Zott, Benedikt
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.04.2025
• Subjects: Adult; Anesthetics, Inhalation - adverse effects; Anesthetics, Inhalation - pharmacology; Cerebrospinal Fluid - drug effects; Cerebrospinal Fluid - physiology; Female; Glymphatic System - drug effects; Gray Matter - diagnostic imaging; Gray Matter - drug effects; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Perioperative Medicine: Clinical Science; Sevoflurane - adverse effects; Sevoflurane - pharmacology; Young Adult

Background: According to the model of the glymphatic system, the directed flow of cerebrospinal fluid (CSF) is a driver of waste clearance from the brain. In sleep, glymphatic transport is enhanced, but it is unclear how it is affected by anesthesia. Animal research indicates partially opposing effe...