TARGETING S100A9-TLR2 AXIS CONTROLS MACROPHAGE NLRP3 INFLAMMASOME ACTIVATION IN FATTY LIVER ISCHEMIA REPERFUSION INJURY

• Published in: Shock (Augusta, Ga.) Vol. 63; no. 2; p. 292
• Main Authors: Sheng, Mingwei, Liu, Weihua, Cao, Yingli, Wang, Shixuan, Lin, Yuanbang, Yu, Wenli
• Format: Journal Article
• Language: English
• Published: United States 01.02.2025
• Subjects: Animals; Calgranulin B - genetics; Calgranulin B - metabolism; Fatty Liver - metabolism; Fatty Liver - pathology; Inflammasomes - metabolism; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Signal Transduction; Toll-Like Receptor 2 - metabolism

Liver ischemia reperfusion (IR) injury significantly impacts clinical outcomes by increasing the risk of hepatic dysfunction after liver surgery. Fatty livers are more susceptible to IR stress. Recent studies have demonstrated that S100A9 plays a crucial role in both IR injury and the progression of...