A genotype-controlled analysis of plasma dopamine β-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic function

• Published in: Biological psychiatry (1969) Vol. 52; no. 12; pp. 1151 - 1158
• Main Authors: Köhnke, Michael D, Zabetian, Cyrus P, Anderson, George M, Kolb, Werner, Gaertner, Ines, Buchkremer, Gerhard, Vonthein, Reinhard, Schick, Sandra, Lutz, Ulrich, Köhnke, Annette M, Cubells, Joseph F
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.12.2002; Elsevier Science
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcohol Withdrawal Delirium - blood; Alcoholism; Alcoholism - blood; Alcoholism - genetics; Alleles; Biological and medical sciences; Dopamine beta-Hydroxylase - blood; Dopamine beta-Hydroxylase - genetics; Genotype; Germany; Heterozygote; HPLC; Humans; Male; Medical sciences; Norepinephrine; Norepinephrine - blood; Norepinephrine - genetics; PCR; polymorphism; Polymorphism, Genetic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Substance Withdrawal Syndrome - blood; withdrawal; Germany; Norepinephrine; polymorphism; withdrawal; alcoholism; HPLC; PCR; Human; Dopamine β-monooxygenase; Dopamine; Poison withdrawal; Ethanol; Enzyme; Alcoholism; Etiopathogenesis; Exploration; Genotype; Delirium tremens; Allele; Genetics; Oxidoreductases; Comparative study

Norepinephrine and dopamine mediate important aspects of alcoholism and alcohol withdrawal. Dopamine-β-hydroxylase (DβH) converts dopamine to norepinephrine. A recent study demonstrated a strong association between variance in plasma DβH activity and a novel polymorphism (DBH-1021C→T) at the structu...