Pre-clinical pharmacokinetic-pharmacodynamic modelling and biodistribution studies of donepezil hydrochloride by a validated HPLC method
A simple, sensitive and robust HPLC-PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an inte...
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Published in | RSC advances Vol. 8; no. 44; pp. 24740 - 24749 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
01.01.2018
The Royal Society of Chemistry |
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Abstract | A simple, sensitive and robust HPLC-PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an internal standard. Separation of the analytes was achieved on a Waters Nova-Pak C18 column (3.9 × 150 mm, 4 μm) using an isocratic mobile phase of acetonitrile and ammonium formate (pH 6.4; 0.01 M) (62 : 38% v/v) at a flow rate of 1 mL min
. All validation parameter results were within the acceptable range described in the guidelines for bioanalytical method validation. The method showed linearity in the concentration range of 50-5000 ng mL
with LOD of 20 ng mL
and LLOQ of 50 ng mL
. Moreover, the advantage of this method over previously published methods is the short analysis run time of 6 min in HPLC itself, alongside its application not only for plasma samples but also in tissues, with low LLOQ. The method was successfully applied for studying the compartmental pharmacokinetics, tissue distribution and pharmacodynamics. A two-compartmental micro model was statistically fitted for the assessment of pharmacokinetic parameters. The tissue distribution studies suggest that the kidneys, lungs and liver are the primarily responsible organs for metabolism and elimination of DNP. Pharmacodynamic studies were performed by measuring acetylcholinesterase inhibitory activity of DNP, which indicated that the pharmacokinetic and pharmacodynamic data are in correlation with each other. |
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AbstractList | A simple, sensitive and robust HPLC–PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an internal standard. Separation of the analytes was achieved on a Waters Nova-Pak C18 column (3.9 × 150 mm, 4 μm) using an isocratic mobile phase of acetonitrile and ammonium formate (pH 6.4; 0.01 M) (62 : 38% v/v) at a flow rate of 1 mL min
−1
. All validation parameter results were within the acceptable range described in the guidelines for bioanalytical method validation. The method showed linearity in the concentration range of 50–5000 ng mL
−1
with LOD of 20 ng mL
−1
and LLOQ of 50 ng mL
−1
. Moreover, the advantage of this method over previously published methods is the short analysis run time of 6 min in HPLC itself, alongside its application not only for plasma samples but also in tissues, with low LLOQ. The method was successfully applied for studying the compartmental pharmacokinetics, tissue distribution and pharmacodynamics. A two-compartmental micro model was statistically fitted for the assessment of pharmacokinetic parameters. The tissue distribution studies suggest that the kidneys, lungs and liver are the primarily responsible organs for metabolism and elimination of DNP. Pharmacodynamic studies were performed by measuring acetylcholinesterase inhibitory activity of DNP, which indicated that the pharmacokinetic and pharmacodynamic data are in correlation with each other.
A simple, sensitive and robust HPLC–PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. A simple, sensitive and robust HPLC-PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an internal standard. Separation of the analytes was achieved on a Waters Nova-Pak C18 column (3.9 × 150 mm, 4 μm) using an isocratic mobile phase of acetonitrile and ammonium formate (pH 6.4; 0.01 M) (62 : 38% v/v) at a flow rate of 1 mL min-1. All validation parameter results were within the acceptable range described in the guidelines for bioanalytical method validation. The method showed linearity in the concentration range of 50-5000 ng mL-1 with LOD of 20 ng mL-1 and LLOQ of 50 ng mL-1. Moreover, the advantage of this method over previously published methods is the short analysis run time of 6 min in HPLC itself, alongside its application not only for plasma samples but also in tissues, with low LLOQ. The method was successfully applied for studying the compartmental pharmacokinetics, tissue distribution and pharmacodynamics. A two-compartmental micro model was statistically fitted for the assessment of pharmacokinetic parameters. The tissue distribution studies suggest that the kidneys, lungs and liver are the primarily responsible organs for metabolism and elimination of DNP. Pharmacodynamic studies were performed by measuring acetylcholinesterase inhibitory activity of DNP, which indicated that the pharmacokinetic and pharmacodynamic data are in correlation with each other.A simple, sensitive and robust HPLC-PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an internal standard. Separation of the analytes was achieved on a Waters Nova-Pak C18 column (3.9 × 150 mm, 4 μm) using an isocratic mobile phase of acetonitrile and ammonium formate (pH 6.4; 0.01 M) (62 : 38% v/v) at a flow rate of 1 mL min-1. All validation parameter results were within the acceptable range described in the guidelines for bioanalytical method validation. The method showed linearity in the concentration range of 50-5000 ng mL-1 with LOD of 20 ng mL-1 and LLOQ of 50 ng mL-1. Moreover, the advantage of this method over previously published methods is the short analysis run time of 6 min in HPLC itself, alongside its application not only for plasma samples but also in tissues, with low LLOQ. The method was successfully applied for studying the compartmental pharmacokinetics, tissue distribution and pharmacodynamics. A two-compartmental micro model was statistically fitted for the assessment of pharmacokinetic parameters. The tissue distribution studies suggest that the kidneys, lungs and liver are the primarily responsible organs for metabolism and elimination of DNP. Pharmacodynamic studies were performed by measuring acetylcholinesterase inhibitory activity of DNP, which indicated that the pharmacokinetic and pharmacodynamic data are in correlation with each other. A simple, sensitive and robust HPLC–PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an internal standard. Separation of the analytes was achieved on a Waters Nova-Pak C18 column (3.9 × 150 mm, 4 μm) using an isocratic mobile phase of acetonitrile and ammonium formate (pH 6.4; 0.01 M) (62 : 38% v/v) at a flow rate of 1 mL min −1 . All validation parameter results were within the acceptable range described in the guidelines for bioanalytical method validation. The method showed linearity in the concentration range of 50–5000 ng mL −1 with LOD of 20 ng mL −1 and LLOQ of 50 ng mL −1 . Moreover, the advantage of this method over previously published methods is the short analysis run time of 6 min in HPLC itself, alongside its application not only for plasma samples but also in tissues, with low LLOQ. The method was successfully applied for studying the compartmental pharmacokinetics, tissue distribution and pharmacodynamics. A two-compartmental micro model was statistically fitted for the assessment of pharmacokinetic parameters. The tissue distribution studies suggest that the kidneys, lungs and liver are the primarily responsible organs for metabolism and elimination of DNP. Pharmacodynamic studies were performed by measuring acetylcholinesterase inhibitory activity of DNP, which indicated that the pharmacokinetic and pharmacodynamic data are in correlation with each other. A simple, sensitive and robust HPLC-PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an internal standard. Separation of the analytes was achieved on a Waters Nova-Pak C18 column (3.9 × 150 mm, 4 μm) using an isocratic mobile phase of acetonitrile and ammonium formate (pH 6.4; 0.01 M) (62 : 38% v/v) at a flow rate of 1 mL min . All validation parameter results were within the acceptable range described in the guidelines for bioanalytical method validation. The method showed linearity in the concentration range of 50-5000 ng mL with LOD of 20 ng mL and LLOQ of 50 ng mL . Moreover, the advantage of this method over previously published methods is the short analysis run time of 6 min in HPLC itself, alongside its application not only for plasma samples but also in tissues, with low LLOQ. The method was successfully applied for studying the compartmental pharmacokinetics, tissue distribution and pharmacodynamics. A two-compartmental micro model was statistically fitted for the assessment of pharmacokinetic parameters. The tissue distribution studies suggest that the kidneys, lungs and liver are the primarily responsible organs for metabolism and elimination of DNP. Pharmacodynamic studies were performed by measuring acetylcholinesterase inhibitory activity of DNP, which indicated that the pharmacokinetic and pharmacodynamic data are in correlation with each other. A simple, sensitive and robust HPLC–PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent acetylcholinesterase inhibitor in rat plasma and tissues. All biological samples were prepared by the solid-phase extraction method using loratadine as an internal standard. Separation of the analytes was achieved on a Waters Nova-Pak C18 column (3.9 × 150 mm, 4 μm) using an isocratic mobile phase of acetonitrile and ammonium formate (pH 6.4; 0.01 M) (62 : 38% v/v) at a flow rate of 1 mL min−1. All validation parameter results were within the acceptable range described in the guidelines for bioanalytical method validation. The method showed linearity in the concentration range of 50–5000 ng mL−1 with LOD of 20 ng mL−1 and LLOQ of 50 ng mL−1. Moreover, the advantage of this method over previously published methods is the short analysis run time of 6 min in HPLC itself, alongside its application not only for plasma samples but also in tissues, with low LLOQ. The method was successfully applied for studying the compartmental pharmacokinetics, tissue distribution and pharmacodynamics. A two-compartmental micro model was statistically fitted for the assessment of pharmacokinetic parameters. The tissue distribution studies suggest that the kidneys, lungs and liver are the primarily responsible organs for metabolism and elimination of DNP. Pharmacodynamic studies were performed by measuring acetylcholinesterase inhibitory activity of DNP, which indicated that the pharmacokinetic and pharmacodynamic data are in correlation with each other. |
Author | Krishna, Kowthavarapu Venkata Singhvi, Gautam Saha, Ranendra Narayana Dubey, Sunil Kumar |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35542150$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.jchromb.2005.10.031 10.1007/s00210-014-1081-2 10.1038/s41598-017-03016-0 10.1016/j.jpba.2018.02.061 10.3233/JAD-2010-091579 10.1016/S0021-9258(19)52451-6 10.2478/V10007-011-0035-1 10.2165/00003088-200241100-00003 10.1007/s100720200086 10.1016/j.jep.2014.01.014 10.1007/BF01117450 10.1002/bmc.1709 10.1016/0140-6736(91)92656-M 10.1016/j.jpba.2012.02.008 10.1016/j.jchromb.2015.07.042 10.1056/NEJMoa013128 10.1016/j.jpba.2005.10.017 10.1016/j.jchromb.2011.10.027 10.1038/nrd1958 10.1016/S1570-0232(01)00592-X 10.1016/0006-2952(61)90145-9 10.1111/j.1368-504X.2005.00480.x |
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References | Bond (C8RA03379J-(cit7)/*[position()=1]) 2005; 59 Nakashima (C8RA03379J-(cit15)/*[position()=1]) 2006; 41 de la Torre (C8RA03379J-(cit6)/*[position()=1]) 2010; 20 Khuroo (C8RA03379J-(cit12)/*[position()=1]) 2012; 26 C8RA03379J-(cit18)/*[position()=1] Sharma (C8RA03379J-(cit23)/*[position()=1]) 2015; 388 Eagger (C8RA03379J-(cit3)/*[position()=1]) 1991; 337 Yamaoka (C8RA03379J-(cit19)/*[position()=1]) 1978; 6 Zhan (C8RA03379J-(cit24)/*[position()=1]) 2018; 154 Lipton (C8RA03379J-(cit4)/*[position()=1]) 2006; 5 Yasui-Furukori (C8RA03379J-(cit9)/*[position()=1]) 2002; 768 Koeber (C8RA03379J-(cit16)/*[position()=1]) 2012; 881 Abonassif (C8RA03379J-(cit8)/*[position()=1]) 2011; 61 Bhateria (C8RA03379J-(cit10)/*[position()=1]) 2015; 1001 Lowry (C8RA03379J-(cit22)/*[position()=1]) 1951; 193 Stuart (C8RA03379J-(cit1)/*[position()=1]) 2017; 7 C8RA03379J-(cit17)/*[position()=1] Reisberg (C8RA03379J-(cit5)/*[position()=1]) 2003; 348 Parnetti (C8RA03379J-(cit20)/*[position()=1]) 2002; 23 Radwan (C8RA03379J-(cit14)/*[position()=1]) 2006; 830 Ellman (C8RA03379J-(cit21)/*[position()=1]) 1961; 7 Zhan (C8RA03379J-(cit25)/*[position()=1]) 2014; 152 Prince (C8RA03379J-(cit2)/*[position()=1]) 2016 Jann (C8RA03379J-(cit13)/*[position()=1]) 2002; 41 Noetzli (C8RA03379J-(cit11)/*[position()=1]) 2012; 64 |
References_xml | – volume: 830 start-page: 114 year: 2006 ident: C8RA03379J-(cit14)/*[position()=1] publication-title: J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2005.10.031 contributor: fullname: Radwan – ident: C8RA03379J-(cit17)/*[position()=1] – volume: 388 start-page: 337 year: 2015 ident: C8RA03379J-(cit23)/*[position()=1] publication-title: Naunyn-Schmiedeberg's Arch. Pharmacol. doi: 10.1007/s00210-014-1081-2 contributor: fullname: Sharma – volume: 7 start-page: 2764 year: 2017 ident: C8RA03379J-(cit1)/*[position()=1] publication-title: Sci. Rep. doi: 10.1038/s41598-017-03016-0 contributor: fullname: Stuart – volume: 154 start-page: 23 year: 2018 ident: C8RA03379J-(cit24)/*[position()=1] publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2018.02.061 contributor: fullname: Zhan – volume: 20 start-page: 861 year: 2010 ident: C8RA03379J-(cit6)/*[position()=1] publication-title: J. Alzheimer's Dis. doi: 10.3233/JAD-2010-091579 contributor: fullname: de la Torre – volume: 193 start-page: 265 year: 1951 ident: C8RA03379J-(cit22)/*[position()=1] publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)52451-6 contributor: fullname: Lowry – volume: 61 start-page: 403 year: 2011 ident: C8RA03379J-(cit8)/*[position()=1] publication-title: Acta Pharm. doi: 10.2478/V10007-011-0035-1 contributor: fullname: Abonassif – volume: 41 start-page: 719 year: 2002 ident: C8RA03379J-(cit13)/*[position()=1] publication-title: Clin. Pharmacokinet. doi: 10.2165/00003088-200241100-00003 contributor: fullname: Jann – volume: 23 start-page: s95 year: 2002 ident: C8RA03379J-(cit20)/*[position()=1] publication-title: J. Neurol. Sci. doi: 10.1007/s100720200086 contributor: fullname: Parnetti – volume: 152 start-page: 333 year: 2014 ident: C8RA03379J-(cit25)/*[position()=1] publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2014.01.014 contributor: fullname: Zhan – ident: C8RA03379J-(cit18)/*[position()=1] – volume: 6 start-page: 165 year: 1978 ident: C8RA03379J-(cit19)/*[position()=1] publication-title: J. Pharmacokinet. Pharmacodyn. doi: 10.1007/BF01117450 contributor: fullname: Yamaoka – volume: 26 start-page: 636 year: 2012 ident: C8RA03379J-(cit12)/*[position()=1] publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.1709 contributor: fullname: Khuroo – volume: 337 start-page: 989 year: 1991 ident: C8RA03379J-(cit3)/*[position()=1] publication-title: Lancet doi: 10.1016/0140-6736(91)92656-M contributor: fullname: Eagger – volume: 64 start-page: 16 year: 2012 ident: C8RA03379J-(cit11)/*[position()=1] publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2012.02.008 contributor: fullname: Noetzli – volume: 1001 start-page: 131 year: 2015 ident: C8RA03379J-(cit10)/*[position()=1] publication-title: J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2015.07.042 contributor: fullname: Bhateria – volume: 348 start-page: 1333 year: 2003 ident: C8RA03379J-(cit5)/*[position()=1] publication-title: N. Engl. N. Engl. J. Med. doi: 10.1056/NEJMoa013128 contributor: fullname: Reisberg – volume: 41 start-page: 201 year: 2006 ident: C8RA03379J-(cit15)/*[position()=1] publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2005.10.017 contributor: fullname: Nakashima – volume: 881 start-page: 1 year: 2012 ident: C8RA03379J-(cit16)/*[position()=1] publication-title: J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2011.10.027 contributor: fullname: Koeber – volume: 5 start-page: 160 year: 2006 ident: C8RA03379J-(cit4)/*[position()=1] publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd1958 contributor: fullname: Lipton – volume: 768 start-page: 261 year: 2002 ident: C8RA03379J-(cit9)/*[position()=1] publication-title: J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. doi: 10.1016/S1570-0232(01)00592-X contributor: fullname: Yasui-Furukori – volume-title: World Alzheimer Report 2016 Improving healthcare for people living with dementia. Coverage, Quality and costs now and in the future year: 2016 ident: C8RA03379J-(cit2)/*[position()=1] contributor: fullname: Prince – volume: 7 start-page: 88 year: 1961 ident: C8RA03379J-(cit21)/*[position()=1] publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(61)90145-9 contributor: fullname: Ellman – volume: 59 start-page: 8 year: 2005 ident: C8RA03379J-(cit7)/*[position()=1] publication-title: Int. J. Clin. Pract. doi: 10.1111/j.1368-504X.2005.00480.x contributor: fullname: Bond |
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Snippet | A simple, sensitive and robust HPLC-PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent... A simple, sensitive and robust HPLC–PDA assay was developed and validated for rapid determination of donepezil hydrochloride (DNP), a potent... |
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Title | Pre-clinical pharmacokinetic-pharmacodynamic modelling and biodistribution studies of donepezil hydrochloride by a validated HPLC method |
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