Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

• Published in: Nature cell biology Vol. 12; no. 12; pp. 1154 - 1165
• Main Authors: Singh, Sudha B., Ornatowski, Wojciech, Vergne, Isabelle, Naylor, John, Delgado, Monica, Roberts, Esteban, Ponpuak, Marisa, Master, Sharon, Pilli, Manohar, White, Eileen, Komatsu, Masaaki, Deretic, Vojo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2010; Nature Publishing Group
• Subjects: 631/250/262; 631/80/642/333; 631/80/82/39; Animals; Autophagy; Biochemistry; Biomedical and Life Sciences; Cancer Research; Cardiolipins - metabolism; Cell Biology; Cell death; Cell Line; Crohn's disease; Cytochrome; Developmental Biology; Dynamins; GTP Phosphohydrolases - metabolism; GTP-Binding Proteins - analysis; GTP-Binding Proteins - metabolism; Humans; Interferon; Life Sciences; Mice; Microscopy; Microtubule-Associated Proteins - metabolism; Mitochondria; Mitochondria - chemistry; Mitochondria - metabolism; Mitochondrial Proteins - metabolism; Mortality; Pathogens; Protein Isoforms - metabolism; Sedimentation & deposition; Stem Cells; Tuberculosis; United States > US; Japan

IRGM is a human GTPase that triggers autophagy in response to pathogen infection. On Mycobacteria infection, IRGM binds the mitochondrial cardiolipin to induce mitochondrial fission and a general autophagy response. It can also trigger autophagy-independent mitochondria-mediated cell death. IRGM, a...