Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

• Published in: Frontiers in bioengineering and biotechnology Vol. 8
• Main Authors: Boffito, Monica, Torchio, Alessandro, Tonda-Turo, Chiara, Laurano, Rossella, Gisbert-Garzarán, Miguel, Berkmann, Julia C., Cassino, Claudio, Manzano, Miguel, Duda, Georg N., Vallet-Regí, María, Schmidt-Bleek, Katharina, Ciardelli, Gianluca
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 19.05.2020
• Subjects: Bioengineering and Biotechnology; pH-sensitive mesoporous silica nanoparticles; polyurethane; self-immolative polymer; stimuli-responsive; thermo-sensitive hydrogels; triggered drug release

Injectable therapeutic formulations locally releasing their cargo with tunable kinetics in response to external biochemical/physical cues are gaining interest in the scientific community, with the aim to overcome the cons of traditional administration routes. In this work, we proposed an alternative...