Prognostic significance of ETP phenotype and minimal residual disease in T-ALL: a Children’s Oncology Group study

• Published in: Blood Vol. 142; no. 24; pp. 2069 - 2078
• Main Authors: Wood, Brent L., Devidas, Meenakshi, Summers, Ryan J., Chen, Zhiguo, Asselin, Barbara, Rabin, Karen R., Zweidler-McKay, Patrick A., Winick, Naomi J., Borowitz, Michael J., Carroll, William L., Raetz, Elizabeth A., Loh, Mignon L., Hunger, Stephen P., Dunsmore, Kimberly P., Teachey, David T., Winter, Stuart S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.12.2023; The American Society of Hematology
• Subjects: Child; Disease-Free Survival; Humans; Lymphoid Neoplasia; Neoplasm, Residual - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Prognosis; Young Adult

•Children with T-ALL treated in the COG AALL0434 had excellent EFS and OS independent of the ETP status.•Persistent leukemia after induction was a strong predictor of inferior outcome in patients with non-ETP T-ALL. [Display omitted] The early thymic precursor (ETP) immunophenotype was previously re...