The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial
This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on...
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| Published in | Journal of clinical medicine Vol. 9; no. 5; p. 1283 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
29.04.2020
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2077-0383 2077-0383 |
| DOI | 10.3390/jcm9051283 |
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| Abstract | This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group–time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline. |
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| AbstractList | This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group–time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline. This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group-time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline.This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group-time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline. |
| Author | Yang, Ja-Gyeong Son, Haeun Lee, Jihyeon Park, Hyuntae Kang, Seung Wan Park, Hye Jin Thapa, Ngeemasara Park, Kyung Won Jang, Minwoo |
| AuthorAffiliation | 4 Department of Neurology, Dong-A University College of Medicine, Busan 49201, Korea 2 Laboratory of Smart Healthcare, Dong-A University, Busan 49315, Korea 1 Department of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea 3 Data Center for Korean EEG, College of Nursing, Seoul National University, Seoul 03080, Korea |
| AuthorAffiliation_xml | – name: 3 Data Center for Korean EEG, College of Nursing, Seoul National University, Seoul 03080, Korea – name: 4 Department of Neurology, Dong-A University College of Medicine, Busan 49201, Korea – name: 1 Department of Health Sciences, Graduate School, Dong-A University, Busan 49315, Korea – name: 2 Laboratory of Smart Healthcare, Dong-A University, Busan 49315, Korea |
| Author_xml | – sequence: 1 givenname: Ngeemasara orcidid: 0000-0001-9394-2539 surname: Thapa fullname: Thapa, Ngeemasara – sequence: 2 givenname: Hye Jin surname: Park fullname: Park, Hye Jin – sequence: 3 givenname: Ja-Gyeong surname: Yang fullname: Yang, Ja-Gyeong – sequence: 4 givenname: Haeun surname: Son fullname: Son, Haeun – sequence: 5 givenname: Minwoo surname: Jang fullname: Jang, Minwoo – sequence: 6 givenname: Jihyeon surname: Lee fullname: Lee, Jihyeon – sequence: 7 givenname: Seung Wan surname: Kang fullname: Kang, Seung Wan – sequence: 8 givenname: Kyung Won orcidid: 0000-0002-6788-5267 surname: Park fullname: Park, Kyung Won – sequence: 9 givenname: Hyuntae orcidid: 0000-0002-1976-0005 surname: Park fullname: Park, Hyuntae |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32365533$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3389/fnhum.2017.00658 10.1002/gps.5061 10.1177/1533317512466693 10.1016/j.neuropsychologia.2010.12.031 10.1001/jamanetworkopen.2019.13123 10.1017/S0007114517003452 10.1016/S0140-6736(06)68542-5 10.1177/1073191115602552 10.3390/jcm8070940 10.1016/B978-0-323-28661-9.00002-0 10.1016/j.trci.2016.11.003 10.1093/gerona/glw066 10.1093/geronb/58.2.S93 10.1177/0269215517694677 10.1371/journal.pone.0151487 10.1162/1054746053967094 10.4306/pi.2010.7.2.102 10.1177/1545968309353328 10.1186/s13104-019-4810-2 10.1001/archneurol.2010.159 10.4103/1673-5374.131612 10.1590/bjpt-rbf.2014.0062 10.3389/fnagi.2019.00162 10.1080/13854040590947498 10.1007/s00127-018-1581-3 10.1016/j.neurobiolaging.2005.07.021 10.1016/j.jalz.2011.03.008 10.1016/j.jagp.2014.04.009 10.7326/0003-4819-153-3-201008030-00260 10.1016/j.arr.2017.01.004 10.1089/cpb.2007.0105 10.2196/games.2836 10.1177/1533317514545866 10.1016/j.trci.2019.09.016 10.1016/j.clinph.2007.05.070 10.1162/1054746011470208 10.1212/01.wnl.0000167607.63000.38 10.3389/fneur.2018.01058 10.1186/s11556-018-0199-5 10.1186/s12888-019-2180-x 10.1093/geront/gnz132 10.1111/ggi.12014 10.1016/S0140-6736(17)31363-6 10.3389/fnhum.2014.00112 10.1016/j.biopsycho.2018.11.003 10.1017/S1355617709090626 |
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| Keywords | dementia virtual reality mild cognitive impairment electroencephalogram |
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| References | Daviglus (ref_8) 2010; 153 Mahurin (ref_34) 2006; 20 Makizako (ref_27) 2013; 13 ref_13 (ref_30) 2018; 11 Maseda (ref_47) 2013; 28 Pal (ref_6) 2018; 53 Coyle (ref_32) 2015; 23 Fogarty (ref_31) 2019; 140 Hikichi (ref_50) 2017; 3 Buracchio (ref_45) 2010; 67 Zucchella (ref_10) 2018; 9 ref_19 ref_15 Albert (ref_5) 2011; 7 Chandler (ref_25) 2005; 65 Best (ref_44) 2016; 71 Rasmussen (ref_46) 2019; 2 ref_22 ref_20 (ref_37) 2017; 24 Liao (ref_33) 2019; 11 Optale (ref_12) 2010; 24 Fico (ref_23) 2015; 7 Gauthier (ref_7) 2006; 367 ref_36 Rose (ref_48) 2001; 10 Prichep (ref_29) 2006; 27 Arredondo (ref_17) 2015; 30 Livingston (ref_3) 2017; 390 Rizzo (ref_18) 2005; 14 Martyr (ref_40) 2008; 11 Perianez (ref_35) 2009; 15 Vancampfort (ref_43) 2019; 34 Weniger (ref_21) 2011; 49 Kim (ref_26) 2010; 7 Nascimento (ref_39) 2014; 18 Fritz (ref_41) 2017; 35 Htut (ref_11) 2018; 15 Moreno (ref_14) 2019; 5 Klem (ref_28) 1999; 52 (ref_16) 2014; 9 Reynolds (ref_42) 2016; 71 ref_1 Vein (ref_24) 2007; 118 Neri (ref_38) 2017; 31 ref_2 Georgousopoulou (ref_4) 2018; 119 Clemente (ref_49) 2014; 2 ref_9 Zunzunegui (ref_51) 2003; 58 |
| References_xml | – volume: 11 start-page: 658 year: 2018 ident: ref_30 article-title: Two Different Populations within the Healthy Elderly: Lack of Conflict Detection in Those at Risk of Cognitive Decline publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2017.00658 – volume: 34 start-page: 609 year: 2019 ident: ref_43 article-title: Associations between handgrip strength and mild cognitive impairment in middle-aged and older adults in six low-and middle-income countries publication-title: Int. J. Geriatr. Psychiatry doi: 10.1002/gps.5061 – volume: 28 start-page: 7 year: 2013 ident: ref_47 article-title: Multisensory stimulation for people with dementia: A review of the literature publication-title: Am. J. Alzheimer’s Dis. Other Demen. doi: 10.1177/1533317512466693 – volume: 49 start-page: 518 year: 2011 ident: ref_21 article-title: Egocentric and allocentric memory as assessed by virtual reality in individuals with amnestic mild cognitive impairment publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2010.12.031 – volume: 2 start-page: e1913123 year: 2019 ident: ref_46 article-title: Association of neurocognitive and physical function with gait speed in midlife publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2019.13123 – volume: 119 start-page: 280 year: 2018 ident: ref_4 article-title: Effect of long-term nutraceutical and dietary supplement use on cognition in the elderly: A 10-year systematic review of randomised controlled trials publication-title: Br. J. Nutr. doi: 10.1017/S0007114517003452 – volume: 367 start-page: 1262 year: 2006 ident: ref_7 article-title: Mild cognitive impairment publication-title: Lancet doi: 10.1016/S0140-6736(06)68542-5 – volume: 24 start-page: 183 year: 2017 ident: ref_37 article-title: The trail making test: Association with other neuropsychological measures and normative values for adults aged 55 years and older from a Spanish-Speaking Population-based sample publication-title: Assessment doi: 10.1177/1073191115602552 – ident: ref_1 – ident: ref_9 doi: 10.3390/jcm8070940 – ident: ref_36 doi: 10.1016/B978-0-323-28661-9.00002-0 – volume: 3 start-page: 23 year: 2017 ident: ref_50 article-title: Social interaction and cognitive decline: Results of a 7-year community intervention publication-title: Alzheimer’s Dement. Transl. Res. Clin. Interv. doi: 10.1016/j.trci.2016.11.003 – volume: 71 start-page: 1616 year: 2016 ident: ref_44 article-title: An evaluation of the longitudinal, bidirectional associations between gait speed and cognition in older women and men publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glw066 – volume: 58 start-page: S93 year: 2003 ident: ref_51 article-title: Social networks, social integration, and social engagement determine cognitive decline in community-dwelling Spanish older adults publication-title: J. Gerontol. B Psychol. Sci. Soc. Sci. doi: 10.1093/geronb/58.2.S93 – volume: 31 start-page: 1292 year: 2017 ident: ref_38 article-title: Do virtual reality games improve mobility skills and balance measurements in community-dwelling older adults? Systematic review and meta-analysis publication-title: Clin. Rehabil. doi: 10.1177/0269215517694677 – volume: 7 start-page: 80 year: 2015 ident: ref_23 article-title: A succinct overview of virtual reality technology use in Alzheimer’s disease publication-title: Front. Aging Neurosci. – ident: ref_15 doi: 10.1371/journal.pone.0151487 – volume: 14 start-page: 119 year: 2005 ident: ref_18 article-title: A SWOT analysis of the field of virtual reality rehabilitation and therapy publication-title: Presence Teleoperators Virtual Environ. doi: 10.1162/1054746053967094 – volume: 7 start-page: 102 year: 2010 ident: ref_26 article-title: Korean version of mini mental status examination for dementia screening and its’ short form publication-title: Psychiatry Investig. doi: 10.4306/pi.2010.7.2.102 – volume: 24 start-page: 348 year: 2010 ident: ref_12 article-title: Controlling memory impairment in elderly adults using virtual reality memory training: A randomized controlled pilot study publication-title: Neurorehabilit. Neural Repair doi: 10.1177/1545968309353328 – ident: ref_20 doi: 10.1186/s13104-019-4810-2 – volume: 67 start-page: 980 year: 2010 ident: ref_45 article-title: The trajectory of gait speed preceding mild cognitive impairment publication-title: Arch. Neurol. doi: 10.1001/archneurol.2010.159 – volume: 9 start-page: 888 year: 2014 ident: ref_16 article-title: Virtual reality interface devices in the reorganization of neural networks in the brain of patients with neurological diseases publication-title: Neural Regen. Res. doi: 10.4103/1673-5374.131612 – volume: 18 start-page: 502 year: 2014 ident: ref_39 article-title: Walking training associated with virtual reality-based training increases walking speed of individuals with chronic stroke: Systematic review with meta-analysis publication-title: Braz. J. Phys. Ther. doi: 10.1590/bjpt-rbf.2014.0062 – volume: 52 start-page: 3 year: 1999 ident: ref_28 article-title: The ten-twenty electrode system of the International Federation publication-title: Electroencephalogr. Clin. Neurophysiol. – volume: 11 start-page: 162 year: 2019 ident: ref_33 article-title: Effects of Virtual Reality-Based Physical and Cognitive Training on Executive Function and Dual-Task Gait Performance in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2019.00162 – volume: 20 start-page: 271 year: 2006 ident: ref_34 article-title: Trail making test errors and executive function in schizophrenia and depression publication-title: Clin. Neuropsychol. doi: 10.1080/13854040590947498 – volume: 53 start-page: 1149 year: 2018 ident: ref_6 article-title: Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: A systematic review and meta-analysis publication-title: Soc. Psychiatry Psychiatr. Epidemiol. doi: 10.1007/s00127-018-1581-3 – volume: 27 start-page: 471 year: 2006 ident: ref_29 article-title: Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2005.07.021 – volume: 7 start-page: 270 year: 2011 ident: ref_5 article-title: The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease publication-title: Alzheimer’s Dement. doi: 10.1016/j.jalz.2011.03.008 – volume: 71 start-page: 841 year: 2016 ident: ref_42 article-title: Grip strength and cognitive abilities: Associations in old age publication-title: J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. – volume: 23 start-page: 335 year: 2015 ident: ref_32 article-title: Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: Systematic review of the literature publication-title: Am. J. Geriatr. Psychiatry doi: 10.1016/j.jagp.2014.04.009 – volume: 153 start-page: 176 year: 2010 ident: ref_8 article-title: National Institutes of Health State-of-the-Science Conference statement: Preventing Alzheimer disease and cognitive decline publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-153-3-201008030-00260 – volume: 35 start-page: 112 year: 2017 ident: ref_41 article-title: Handgrip strength as a means of monitoring progression of cognitive decline—A scoping review publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2017.01.004 – volume: 11 start-page: 415 year: 2008 ident: ref_40 article-title: Involving persons with dementia in the evaluation of outdoor environments publication-title: Cyberpsychol. Behav. doi: 10.1089/cpb.2007.0105 – volume: 2 start-page: e6 year: 2014 ident: ref_49 article-title: A functional magnetic resonance imaging assessment of small animals’ phobia using virtual reality as a stimulus publication-title: JMIR Serious Games doi: 10.2196/games.2836 – volume: 30 start-page: 49 year: 2015 ident: ref_17 article-title: Using virtual reality for cognitive training of the elderly publication-title: Am. J. Alzheimer’s Dis. Other Demen. doi: 10.1177/1533317514545866 – volume: 5 start-page: 834 year: 2019 ident: ref_14 article-title: A systematic review of the use of virtual reality and its effects on cognition in individuals with neurocognitive disorders publication-title: Alzheimer’s Dement. Transl. Res. Clin. Interv. doi: 10.1016/j.trci.2019.09.016 – ident: ref_2 – volume: 118 start-page: 1931 year: 2007 ident: ref_24 article-title: EEG correlates in the spectrum of cognitive decline publication-title: Clin. Neurophysiol. doi: 10.1016/j.clinph.2007.05.070 – volume: 10 start-page: 345 year: 2001 ident: ref_48 article-title: Learning and memory in virtual environments: A role in neurorehabilitation? Questions (and occasional answers) from the University of East London publication-title: Presence Teleoperators Virtual Environ. doi: 10.1162/1054746011470208 – volume: 65 start-page: 102 year: 2005 ident: ref_25 article-title: A total score for the CERAD neuropsychological battery publication-title: Neurology doi: 10.1212/01.wnl.0000167607.63000.38 – volume: 9 start-page: 1058 year: 2018 ident: ref_10 article-title: The multidisciplinary approach to Alzheimer’s disease and dementia. A narrative review of non-pharmacological treatment publication-title: Front. Neurol. doi: 10.3389/fneur.2018.01058 – volume: 15 start-page: 1 year: 2018 ident: ref_11 article-title: Effects of physical, virtual reality-based, and brain exercise on physical, cognition, and preference in older persons: A randomized controlled trial publication-title: Eur. Rev. Aging Phys. Act. doi: 10.1186/s11556-018-0199-5 – ident: ref_19 doi: 10.1186/s12888-019-2180-x – ident: ref_22 doi: 10.1093/geront/gnz132 – volume: 13 start-page: 860 year: 2013 ident: ref_27 article-title: Evaluation of multidimensional neurocognitive function using a tablet personal computer: Test–retest reliability and validity in community-dwelling older adults publication-title: Geriatr. Gerontol. Int. doi: 10.1111/ggi.12014 – volume: 390 start-page: 2673 year: 2017 ident: ref_3 article-title: Dementia prevention, intervention, and care publication-title: Lancet doi: 10.1016/S0140-6736(17)31363-6 – ident: ref_13 doi: 10.3389/fnhum.2014.00112 – volume: 140 start-page: 19 year: 2019 ident: ref_31 article-title: Frontal EEG theta/beta ratio during mind wandering episodes publication-title: Biol. Psychol. doi: 10.1016/j.biopsycho.2018.11.003 – volume: 15 start-page: 438 year: 2009 ident: ref_35 article-title: Construct validity of the Trail Making Test: Role of task-switching, working memory, inhibition/interference control, and visuomotor abilities publication-title: J. Int. Neuropsychol. Soc. doi: 10.1017/S1355617709090626 |
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| SubjectTerms | Alzheimer's disease Clinical medicine Cognition & reasoning Cognitive ability Dementia Electroencephalography Executive function Exercise Feasibility studies Fireworks Intervention Memory Older people Virtual reality |
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| Title | The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial |
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