Distinct placental molecular processes associated with early-onset and late-onset preeclampsia

• Published in: Theranostics Vol. 11; no. 10; pp. 5028 - 5044
• Main Authors: Ren, Zhonglu, Gao, Yunfei, Gao, Yue, Liang, Guanmei, Chen, Qian, Jiang, Sijia, Yang, Xiaoxue, Fan, Cuixia, Wang, Haizhen, Wang, Jing, Shi, Yi-Wu, Xiao, Chaoqun, Zhong, Mei, Yang, Xinping
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2021; Ivyspring International Publisher
• Subjects: Blood pressure; Classification; Gene expression; Genomes; Gestational age; Hypertension; Pathogenesis; Placenta; Preeclampsia; Principal components analysis; Research Paper; clinical subtypes; placenta; molecular mechanism; preeclampsia; transcriptome

Patients with preeclampsia display a spectrum of onset time and severity of clinical presentation, yet the underlying molecular bases for the early-onset and late-onset clinical subtypes are not known. Although several transcriptome studies have been done on placentae from PE patients, only a small...