Advances in metal-assisted non-electrophilic fluoroalkylation reactions of organic compounds

• Published in: Coordination chemistry reviews Vol. 285; pp. 76 - 108
• Main Authors: Lantaño, Beatriz, Torviso, M. Rosario, Bonesi, S.M., Barata-Vallejo, S., Postigo, Al
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.02.2015
• Subjects: Fluoroalkylation of aromatics; Metal-assisted trifluoromethylation; Trifluoromethylation by metal–organic species; DAST; SArH; SET; PT; DMSO; RfX; pTSA; Bpy; SNAr; Bpin; CF3TMS; TFA; BHT; TBHP; TMSCF2H; TPGS-750-M; Metal-assisted trifluoromethylation; DBU; Boc; HMPA; RuPhos; Xantphos; DMF; DME; TIPS; Trifluoromethylation by metal–organic species; Fluoroalkylation of aromatics; DMI; Phen; SRN1; TESCF3; Boc2O; DCE; TMEDA; phenCu(Rf); dtbbpy; DCM; ET; NMP; HR ESI-MS; TMP; ppy; DPEphos; r.t; Dabco; TMS; TfO; t-BuXPhos

•Metal-assisted fluoroalkylations are obtained through polar and radical reactions.•Fluoroalkylations using RfX or nucleophilic agents are used in the presence of metals.•Aryl halides, boronic acids and aniline precursors can be substituted with Rf groups.•Homolytic aromatic substitutions with Rf gr...