Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

• Published in: Science translational medicine Vol. 7; no. 302; p. 302ra133
• Main Authors: Garcia-Murillas, Isaac, Schiavon, Gaia, Weigelt, Britta, Ng, Charlotte, Hrebien, Sarah, Cutts, Rosalind J, Cheang, Maggie, Osin, Peter, Nerurkar, Ashutosh, Kozarewa, Iwanka, Garrido, Javier Armisen, Dowsett, Mitch, Reis-Filho, Jorge S, Smith, Ian E, Turner, Nicholas C
• Format: Journal Article
• Language: English
• Published: United States 26.08.2015
• Subjects: Breast Neoplasms - blood; Breast Neoplasms - genetics; Breast Neoplasms - pathology; DNA, Neoplasm - genetics; Female; High-Throughput Nucleotide Sequencing; Humans; Mutation; Neoplasm, Residual; Precision Medicine; Recurrence

The identification of early-stage breast cancer patients at high risk of relapse would allow tailoring of adjuvant therapy approaches. We assessed whether analysis of circulating tumor DNA (ctDNA) in plasma can be used to monitor for minimal residual disease (MRD) in breast cancer. In a prospective...