C5-selective trifluoromethylation of 8-amino quinolines via photoredox catalysis

• Published in: Journal of fluorine chemistry Vol. 219; pp. 23 - 28
• Main Authors: Tian, Chao, Yang, Li-Ming, Tian, Hai-Tao, An, Guang-Hui, Li, Guang-Ming
• Format: Journal Article
• Language: English
• Published: LAUSANNE Elsevier B.V 01.03.2019; Elsevier; Elsevier BV
• Subjects: 8-Aminoquinolines; Aminoquinolines; Catalysis; Chemistry; Chemistry, Inorganic & Nuclear; Chemistry, Organic; Organic chemistry; Organic compounds; Para-selective C[sbnd]H activation; Photoredox catalysis; Physical Sciences; Quinoline; Quinolines; Science & Technology; Trifluoromethylation; Photoredox catalysis; Para-selective CH activation; Trifluoromethylation; 8-Aminoquinolines; REAGENT; AMINOQUINOLINES; FLUORINATION; Para-selective C-H activation; C-H TRIFLUOROMETHYLATION; PERFLUOROALKYLATION

[Display omitted] •A transition-metal free, site-selective, visible-light mediated trifluoromethylation protocol was achieved.•The reaction was carried in environmental benign solvent enabled by organo photocatalyst.•This protocol allowed rapid access to a series of aminoquinoline amides, including...