Alterations in factors associated with diabetic retinopathy combined with thrombosis: A review

Diabetic retinopathy (DR) is one of the most common and serious microvascular complications of diabetes mellitus, the incidence of which has been increasing annually, and it is the main cause of vision loss in diabetic patients and a common cause of blindness. It is now found that thrombosis plays a...

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Published inMedicine (Baltimore) Vol. 102; no. 31; p. e34373
Main Authors Wei, Haiyan, Xiao, Xiaoping, Zeng, Shuqin, Liu, Ye, Liu, Xiaofang, Zeng, Tianyu, Xu, Pengxiang, Xia, Wenyan, Guo, Li, Hong, Shihua, Lv, Weiming, Chen, Yijian, Xu, Rong
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins 04.08.2023
Subjects
Diabetes Mellitus
Diabetic Retinopathy - epidemiology
Humans
Narrative Review
Retinal Vessels
Thrombosis - complications
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Abstract Diabetic retinopathy (DR) is one of the most common and serious microvascular complications of diabetes mellitus, the incidence of which has been increasing annually, and it is the main cause of vision loss in diabetic patients and a common cause of blindness. It is now found that thrombosis plays a crucial role in the disease progression in DR patients, and the final vision loss in DR may be related to the occurrence of thrombosis in the retinal vessels, which is dominated by abnormal endothelial cell function, together with platelet dysfunction, imbalance of coagulation and fibrinolytic function, and related alterations of inflammatory factors leading to the main cause of thrombotic disease in DR patients. In this review, we examine the role between DR and thrombosis and the association of each factor, including endothelial dysfunction; platelet dysfunction; coagulation-fibrinolytic imbalance; and alterations in inflammatory factors.
AbstractList Diabetic retinopathy (DR) is one of the most common and serious microvascular complications of diabetes mellitus, the incidence of which has been increasing annually, and it is the main cause of vision loss in diabetic patients and a common cause of blindness. It is now found that thrombosis plays a crucial role in the disease progression in DR patients, and the final vision loss in DR may be related to the occurrence of thrombosis in the retinal vessels, which is dominated by abnormal endothelial cell function, together with platelet dysfunction, imbalance of coagulation and fibrinolytic function, and related alterations of inflammatory factors leading to the main cause of thrombotic disease in DR patients. In this review, we examine the role between DR and thrombosis and the association of each factor, including endothelial dysfunction; platelet dysfunction; coagulation-fibrinolytic imbalance; and alterations in inflammatory factors.
Author Guo, Li
Wei, Haiyan
Liu, Xiaofang
Chen, Yijian
Xu, Pengxiang
Lv, Weiming
Xiao, Xiaoping
Hong, Shihua
Liu, Ye
Xia, Wenyan
Xu, Rong
Zeng, Tianyu
Zeng, Shuqin
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  orcidid: 0000-0002-2028-478
  surname: Xu
  fullname: Xu, Rong
  organization: The First Affiliated Hospital of Gannan Medical University, Ganzhou, P.R. China
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Snippet Diabetic retinopathy (DR) is one of the most common and serious microvascular complications of diabetes mellitus, the incidence of which has been increasing...
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SubjectTerms Diabetes Mellitus
Diabetic Retinopathy - epidemiology
Humans
Narrative Review
Retinal Vessels
Thrombosis - complications
Title Alterations in factors associated with diabetic retinopathy combined with thrombosis: A review
URI https://www.ncbi.nlm.nih.gov/pubmed/37543800
https://search.proquest.com/docview/2846923291
https://pubmed.ncbi.nlm.nih.gov/PMC10403020
Volume 102
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