Circulating MicroRNAs as Potential Predictors of Anthracycline-Induced Troponin Elevation in Breast Cancer Patients: Diverging Effects of Doxorubicin and Epirubicin

• Published in: Journal of clinical medicine Vol. 9; no. 5; p. 1418
• Main Authors: Gioffré, Sonia, Chiesa, Mattia, Cardinale, Daniela Maria, Ricci, Veronica, Vavassori, Chiara, Cipolla, Carlo Maria, Masson, Serge, Sandri, Maria Teresa, Salvatici, Michela, Ciceri, Fabio, Latini, Roberto, Staszewsky, Lidia Irene, Pompilio, Giulio, Colombo, Gualtiero I., D’Alessandra, Yuri
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.05.2020; MDPI
• Subjects: Biomarkers; Breast cancer; Cancer therapies; Cardiac function; Cardiomyocytes; Cardiotoxicity; Chemotherapy; Clinical medicine; Gene expression; Heart failure; Investigations; MicroRNAs; Plasma; Software; Toxicity; United States > US; microRNA; biomarkers; anthracyclines

Anthracyclines are anti-neoplastic drugs presenting cardiotoxicity as a side effect. Cardiac troponins (cTn) and echocardiography are currently used to assess cardiac damage and dysfunction, but early biomarkers identifying patients in need of preventive treatments remain a partially met need. Circu...