O-alkylated quercetins with selective acetylcholinesterase and β-secretase inhibitions from Melicope glabra leaves, and their flavonols profile by LC-ESI-Q-TOF/MS

• Published in: Journal of functional foods Vol. 84; p. 104602
• Main Authors: Baiseitova, Aizhamal, Shah, Abdul Bari, Kim, Jeong Yoon, Ban, Yeong Jun, Kim, Jeong Ho, Nafiah, Mohd Azlan, Park, Ki Hun
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2021; Elsevier
• Subjects: Acetylcholinesterase; Antioxidant; Melicope glabra; Pteleifolosin C; Pteleifolosin E; β-secretase; β-secretase; Melicope glabra; Acetylcholinesterase; Antioxidant; Pteleifolosin C; Pteleifolosin E

[Display omitted] •Quercetin derivatives (1-13) including the new (2) were isolated from M. glabra.•O-Alkylated quercetins were selective inhibitory potential toward hAChE and BACE1.•All compounds from M. glabra had a significant antioxidant potentials.•LC-ESI-Q-TOF/MS disclosed inhibitors as main m...