The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca

We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal plant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque red...

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Published inMicrobiological research Vol. 163; no. 2; pp. 136 - 139
Main Authors Melo, Fernando L., Benati, Fabricio J., Junior, Walter Antonio Roman, de Mello, João Carlos Palazzo, Nozawa, Carlos, Linhares, Rosa Elisa Carvalho
Format Journal Article
LanguageEnglish
Published Germany Elsevier GmbH 01.01.2008
Subjects
Aliphatic nitro compound
Animals
Antiviral activity
Antiviral Agents - pharmacology
Bovine herpesvirus
Brazil
Cattle
Cell Line, Tumor
Cytopathogenic Effect, Viral - drug effects
Herpesvirus
Herpesvirus 1, Bovine - drug effects
Heteropteris
Heteropteris aphrodisiaca
Humans
Inhibitory Concentration 50
Malpighiaceae
Nitro Compounds - pharmacology
Plant Extracts - pharmacology
Plant Roots - chemistry
Plants, Medicinal - chemistry
Poliovirus
Poliovirus - drug effects
Viral Plaque Assay
Brazil
Bovine herpesvirus
Heteropteris aphrodisiaca
Poliovirus
Aliphatic nitro compound
Antiviral activity
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Abstract We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal plant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 cells, and the 50% inhibitory concentration (IC50) were 22.01 μg/ml (selectivity index (SI)=2.83) and 21.10 μg/ml (SI=2.95), respectively. At the highest concentration of the drug (40 μg/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains.
AbstractList We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal plant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 cells, and the 50% inhibitory concentration (IC50) were 22.01 microg/ml (selectivity index (SI)=2.83) and 21.10 microg/ml (SI=2.95), respectively. At the highest concentration of the drug (40 microg/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains.
We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal plant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 cells, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI)=2.83) and 21.10 mu g /ml (SI=2.95), respectively. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains.
We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal plant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 cells, and the 50% inhibitory concentration (IC50) were 22.01 μg/ml (selectivity index (SI)=2.83) and 21.10 μg/ml (SI=2.95), respectively. At the highest concentration of the drug (40 μg/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains.
Author Benati, Fabricio J.
de Mello, João Carlos Palazzo
Nozawa, Carlos
Melo, Fernando L.
Linhares, Rosa Elisa Carvalho
Junior, Walter Antonio Roman
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Issue 2
Keywords Bovine herpesvirus
Heteropteris aphrodisiaca
Poliovirus
Aliphatic nitro compound
Antiviral activity
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Snippet We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian...
We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian...
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SubjectTerms Aliphatic nitro compound
Animals
Antiviral activity
Antiviral Agents - pharmacology
Bovine herpesvirus
Brazil
Cattle
Cell Line, Tumor
Cytopathogenic Effect, Viral - drug effects
Herpesvirus
Herpesvirus 1, Bovine - drug effects
Heteropteris
Heteropteris aphrodisiaca
Humans
Inhibitory Concentration 50
Malpighiaceae
Nitro Compounds - pharmacology
Plant Extracts - pharmacology
Plant Roots - chemistry
Plants, Medicinal - chemistry
Poliovirus
Poliovirus - drug effects
Viral Plaque Assay
Title The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
URI https://dx.doi.org/10.1016/j.micres.2006.03.011
https://www.ncbi.nlm.nih.gov/pubmed/16735108
https://search.proquest.com/docview/19889144
Volume 163
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