Redox-neutral ortho -C–H amination of pinacol arylborates via palladium( ii )/norbornene catalysis for aniline synthesis

• Published in: Chemical science (Cambridge) Vol. 10; no. 36; pp. 8384 - 8389
• Main Authors: Chen, Shuqing, Wang, Peng, Cheng, Hong-Gang, Yang, Chihui, Zhou, Qianghui
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 28.09.2019; Royal Society of Chemistry
• Subjects: Aniline; Aromatic compounds; Catalysis; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Deuterium; Iodides; Organic chemistry; Palladium; Physical Sciences; Protonation; Science & Technology; Transition metals; AROMATIC FUNCTIONALIZATION; PALLADIUM; NORBORNENE; CARBON; ARYLATION; ELECTROPHILIC AMINATION; ARYL IODIDES; CATELLANI REACTION; PD/NORBORNENE; ARYLBORONIC ACIDS

A palladium( ii )/norbornene cooperative catalysis enabled redox-neutral ortho -C–H amination of pinacol aryl- or heteroarylborates for the synthesis of structurally diverse anilines is reported. This method is scalable, robust (tolerance of air and moisture), phosphine ligand-free, and compatible w...