Supplementation of Lactobacillus plantarum (TCI227) Prevented Potassium-Oxonate-Induced Hyperuricemia in Rats

Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus plantarum can improve microbiota and immune regulation, as well as inhibit uric acid production. However, it is not clear whether L. plantarum...

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Published inNutrients Vol. 14; no. 22; p. 4832
Main Authors Chien, Chih-Yu, Chien, Yu-Jou, Lin, Yung-Hao, Lin, Yung-Hsiang, Chan, Shu-Ting, Hu, Wei-Chun, Wu, Han-Fang, Chiang, Chi-Fu, Hsu, Chin-Lin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 15.11.2022
MDPI
Subjects
Animals
Bacteria
Chronic illnesses
Diet
Dietary Supplements
Disease
Feces
Hyperuricemia - chemically induced
Hyperuricemia - prevention & control
Kidneys
Lactobacillus plantarum - physiology
Male
Metabolism
Microbiota
Potassium
Probiotics
Rats
Rats, Sprague-Dawley
Rheumatism
Triglycerides
Uric Acid
Urine
United Kingdom > UK
Germany
Taiwan
microbiota
hyperuricemia
Lactobacillus plantarum
uric acid
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Abstract Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus plantarum can improve microbiota and immune regulation, as well as inhibit uric acid production. However, it is not clear whether L. plantarum can improve HC and intestinal microbiota. We used potassium oxonate (PO) to induce HC in male SD rats and then treated them with L. plantarum TCI227 in a dose-dependent manner (HC + LD, HC + MD, HC + HD) for 4 weeks. We examined organ weight, conducted biochemical examinations of blood and urine, and analyzed the intestinal microbiota in feces through a 16s rDNA sequence analysis. In this study, TCI227 improved body weight, decreased creatinine and serum uric acid, and increased urine uric acid compared to the HC group. Furthermore, TCI227 increased short-chain fatty acids (SCFAs). In the fecal microbiota (family), TCI227 increased the level of Lactobacillaceae and then decreased the levels of Deferribacteres and Prevotellaceae compared to the HC group. Finally, in the fecal microbiota (genus), TCI227 decreased the level of Prevotella and then increased the levels of Lactobacillus and Ruminococcus compared to the HC group. This study suggested that TCI227 can improve HC and can change the composition of intestinal microbiota in PO-induced male HC SD rats.
AbstractList Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus plantarum can improve microbiota and immune regulation, as well as inhibit uric acid production. However, it is not clear whether L. plantarum can improve HC and intestinal microbiota. We used potassium oxonate (PO) to induce HC in male SD rats and then treated them with L. plantarum TCI227 in a dose-dependent manner (HC + LD, HC + MD, HC + HD) for 4 weeks. We examined organ weight, conducted biochemical examinations of blood and urine, and analyzed the intestinal microbiota in feces through a 16s rDNA sequence analysis. In this study, TCI227 improved body weight, decreased creatinine and serum uric acid, and increased urine uric acid compared to the HC group. Furthermore, TCI227 increased short-chain fatty acids (SCFAs). In the fecal microbiota (family), TCI227 increased the level of Lactobacillaceae and then decreased the levels of Deferribacteres and Prevotellaceae compared to the HC group. Finally, in the fecal microbiota (genus), TCI227 decreased the level of Prevotella and then increased the levels of Lactobacillus and Ruminococcus compared to the HC group. This study suggested that TCI227 can improve HC and can change the composition of intestinal microbiota in PO-induced male HC SD rats.
Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus plantarum can improve microbiota and immune regulation, as well as inhibit uric acid production. However, it is not clear whether L. plantarum can improve HC and intestinal microbiota. We used potassium oxonate (PO) to induce HC in male SD rats and then treated them with L. plantarum TCI227 in a dose-dependent manner (HC + LD, HC + MD, HC + HD) for 4 weeks. We examined organ weight, conducted biochemical examinations of blood and urine, and analyzed the intestinal microbiota in feces through a 16s rDNA sequence analysis. In this study, TCI227 improved body weight, decreased creatinine and serum uric acid, and increased urine uric acid compared to the HC group. Furthermore, TCI227 increased short-chain fatty acids (SCFAs). In the fecal microbiota (family), TCI227 increased the level of Lactobacillaceae and then decreased the levels of Deferribacteres and Prevotellaceae compared to the HC group. Finally, in the fecal microbiota (genus), TCI227 decreased the level of Prevotella and then increased the levels of Lactobacillus and Ruminococcus compared to the HC group. This study suggested that TCI227 can improve HC and can change the composition of intestinal microbiota in PO-induced male HC SD rats.Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus plantarum can improve microbiota and immune regulation, as well as inhibit uric acid production. However, it is not clear whether L. plantarum can improve HC and intestinal microbiota. We used potassium oxonate (PO) to induce HC in male SD rats and then treated them with L. plantarum TCI227 in a dose-dependent manner (HC + LD, HC + MD, HC + HD) for 4 weeks. We examined organ weight, conducted biochemical examinations of blood and urine, and analyzed the intestinal microbiota in feces through a 16s rDNA sequence analysis. In this study, TCI227 improved body weight, decreased creatinine and serum uric acid, and increased urine uric acid compared to the HC group. Furthermore, TCI227 increased short-chain fatty acids (SCFAs). In the fecal microbiota (family), TCI227 increased the level of Lactobacillaceae and then decreased the levels of Deferribacteres and Prevotellaceae compared to the HC group. Finally, in the fecal microbiota (genus), TCI227 decreased the level of Prevotella and then increased the levels of Lactobacillus and Ruminococcus compared to the HC group. This study suggested that TCI227 can improve HC and can change the composition of intestinal microbiota in PO-induced male HC SD rats.
Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus plantarum can improve microbiota and immune regulation, as well as inhibit uric acid production. However, it is not clear whether L. plantarum can improve HC and intestinal microbiota. We used potassium oxonate (PO) to induce HC in male SD rats and then treated them with L. plantarum TCI227 in a dose-dependent manner (HC + LD, HC + MD, HC + HD) for 4 weeks. We examined organ weight, conducted biochemical examinations of blood and urine, and analyzed the intestinal microbiota in feces through a 16s rDNA sequence analysis. In this study, TCI227 improved body weight, decreased creatinine and serum uric acid, and increased urine uric acid compared to the HC group. Furthermore, TCI227 increased short-chain fatty acids (SCFAs). In the fecal microbiota (family), TCI227 increased the level of Lactobacillaceae and then decreased the levels of Deferribacteres and Prevotellaceae compared to the HC group. Finally, in the fecal microbiota (genus), TCI227 decreased the level of Prevotella and then increased the levels of Lactobacillus and Ruminococcus compared to the HC group. This study suggested that TCI227 can improve HC and can change the composition of intestinal microbiota in PO-induced male HC SD rats.
Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that can improve microbiota and immune regulation, as well as inhibit uric acid production. However, it is not clear whether can improve HC and intestinal microbiota. We used potassium oxonate (PO) to induce HC in male SD rats and then treated them with TCI227 in a dose-dependent manner (HC + LD, HC + MD, HC + HD) for 4 weeks. We examined organ weight, conducted biochemical examinations of blood and urine, and analyzed the intestinal microbiota in feces through a 16s rDNA sequence analysis. In this study, TCI227 improved body weight, decreased creatinine and serum uric acid, and increased urine uric acid compared to the HC group. Furthermore, TCI227 increased short-chain fatty acids (SCFAs). In the fecal microbiota (family), TCI227 increased the level of and then decreased the levels of and compared to the HC group. Finally, in the fecal microbiota (genus), TCI227 decreased the level of and then increased the levels of and compared to the HC group. This study suggested that TCI227 can improve HC and can change the composition of intestinal microbiota in PO-induced male HC SD rats.
Author Chien, Chih-Yu
Chien, Yu-Jou
Chan, Shu-Ting
Hu, Wei-Chun
Wu, Han-Fang
Hsu, Chin-Lin
Lin, Yung-Hsiang
Chiang, Chi-Fu
Lin, Yung-Hao
AuthorAffiliation 3 Research & Design Center, TCI Co., Ltd., Taipei 11472, Taiwan
4 Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
2 Baiyuete Limited Company, Shanghai 200071, China
1 Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
AuthorAffiliation_xml – name: 2 Baiyuete Limited Company, Shanghai 200071, China
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Cites_doi 10.3389/fmicb.2016.00455
10.1186/s12866-020-01874-9
10.1016/j.biopha.2016.11.009
10.1111/1756-185X.12010
10.1080/09168451.2020.1781593
10.1159/000360010
10.2147/DDDT.S150825
10.1056/NEJMoa1710895
10.1080/19490976.2015.1134082
10.1152/ajpgi.00151.2019
10.1136/ard.2010.136218
10.1089/chi.2018.0040
10.14202/vetworld.2015.1230-1236
10.1039/C8FO02265H
10.1016/j.jfda.2016.07.003
10.1073/pnas.1401037111
10.3109/13880209.2012.683115
10.1002/mnfr.201500187
10.1038/srep20602
10.1073/pnas.1320393111
10.1007/s00240-017-0965-2
10.3389/fphys.2020.524236
10.1080/07315724.2019.1571454
10.1007/s00394-020-02414-x
10.1016/j.cmet.2017.02.006
10.1097/BOR.0000000000000028
10.1146/annurev-physiol-021113-170343
10.3389/fmicb.2018.02233
10.1155/2016/7390504
10.1007/s00018-015-1995-y
10.1155/2019/3480718
10.4014/jmb.1906.06064
10.1371/journal.pone.0202572
10.1136/gut.52.10.1442
10.1371/journal.pone.0030456
10.5625/lar.2012.28.2.115
10.1124/pr.58.1.6
10.1293/tox.26.29
10.1016/0031-9384(96)00161-8
10.1016/j.bbi.2015.03.016
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Issue 22
Keywords microbiota
hyperuricemia
Lactobacillus plantarum
uric acid
Language English
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References Mandal (ref_3) 2015; 77
Lee (ref_32) 2012; 28
White (ref_16) 2018; 378
Indiani (ref_20) 2018; 14
ref_14
Slim (ref_6) 2017; 56
ref_35
Li (ref_41) 2019; 10
Sarvaiya (ref_27) 2015; 8
ref_10
Shi (ref_28) 2020; 36
Trinchieri (ref_2) 2018; 46
Guo (ref_46) 2021; 60
Abubakar (ref_33) 2010; 3
Chen (ref_42) 2017; 25
Chen (ref_43) 2019; 43
Hongyan (ref_15) 2016; 84
Morrison (ref_17) 2016; 7
Kubota (ref_7) 2019; 2019
Yi (ref_36) 2012; 50
Zmora (ref_37) 2017; 25
Ma (ref_38) 2020; 23
Piao (ref_29) 2013; 26
Kim (ref_13) 2019; 29
Zhong (ref_21) 2015; 59
Andres (ref_11) 2014; 10
Yu (ref_40) 2018; 9
Dalbeth (ref_24) 2010; 69
Xu (ref_44) 2019; 317
Han (ref_45) 2020; 34
Li (ref_18) 2017; 11
Akram (ref_1) 2020; 84
Torralba (ref_5) 2012; 15
Kratzer (ref_23) 2014; 111
Bardin (ref_4) 2014; 26
Wong (ref_9) 2014; 39
Sica (ref_31) 2015; 72
Jiang (ref_19) 2015; 48
Chang (ref_22) 2014; 111
Lv (ref_34) 2020; 11
Guo (ref_8) 2016; 6
Pacher (ref_25) 2006; 58
Mosca (ref_39) 2016; 7
Hsu (ref_12) 2019; 38
Hao (ref_26) 2016; 2016
Imek (ref_30) 1996; 60
Willemsen (ref_47) 2003; 52
References_xml – volume: 7
  start-page: 455
  year: 2016
  ident: ref_39
  article-title: Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2016.00455
– ident: ref_14
  doi: 10.1186/s12866-020-01874-9
– volume: 84
  start-page: 1930
  year: 2016
  ident: ref_15
  article-title: Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats
  publication-title: Biomed. Pharm.
  doi: 10.1016/j.biopha.2016.11.009
– volume: 3
  start-page: 183
  year: 2010
  ident: ref_33
  article-title: Effect of oral administration of aqueous extract of cassia occidentalis l. seeds on serum electrolytes concentration in rats
  publication-title: Bayero J. Pure Appl. Sci.
– volume: 15
  start-page: 499
  year: 2012
  ident: ref_5
  article-title: The interplay between diet, urate transporters and the risk for gout and hyperuricemia: Current and future directions
  publication-title: Int. J. Rheum. Dis.
  doi: 10.1111/1756-185X.12010
– volume: 84
  start-page: 1967
  year: 2020
  ident: ref_1
  article-title: Development and validation of an economical uric acid-Fe(3+)/Fe(2+)-ferrozine-based colorimetric assay to estimate uric acid level of pure and biological samples
  publication-title: Biosci. Biotechnol. Biochem.
  doi: 10.1080/09168451.2020.1781593
– volume: 39
  start-page: 230
  year: 2014
  ident: ref_9
  article-title: Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD
  publication-title: Am. J. Nephrol.
  doi: 10.1159/000360010
– volume: 11
  start-page: 3531
  year: 2017
  ident: ref_18
  article-title: Gut microbiota-derived short-chain fatty acids and kidney diseases
  publication-title: Drug Des. Devel. Ther.
  doi: 10.2147/DDDT.S150825
– volume: 378
  start-page: 1200
  year: 2018
  ident: ref_16
  article-title: Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1710895
– volume: 7
  start-page: 189
  year: 2016
  ident: ref_17
  article-title: Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2015.1134082
– volume: 317
  start-page: G484
  year: 2019
  ident: ref_44
  article-title: Hyperuricemia is associated with impaired intestinal permeability in mice
  publication-title: Am. J. Physiology. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00151.2019
– volume: 69
  start-page: 1738
  year: 2010
  ident: ref_24
  article-title: Hyperuricaemia and gout: State of the art and future perspectives
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/ard.2010.136218
– volume: 14
  start-page: 501
  year: 2018
  ident: ref_20
  article-title: Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review
  publication-title: Child. Obes.
  doi: 10.1089/chi.2018.0040
– volume: 8
  start-page: 1230
  year: 2015
  ident: ref_27
  article-title: Evaluation of antigout activity of Phyllanthus emblica fruit extracts on potassium oxonate-induced gout rat model
  publication-title: Vet. World
  doi: 10.14202/vetworld.2015.1230-1236
– volume: 10
  start-page: 1915
  year: 2019
  ident: ref_41
  article-title: Dietary inulin alleviates diverse stages of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in db/db mice
  publication-title: Food Funct.
  doi: 10.1039/C8FO02265H
– volume: 25
  start-page: 597
  year: 2017
  ident: ref_42
  article-title: Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study
  publication-title: J. Food Drug Anal.
  doi: 10.1016/j.jfda.2016.07.003
– volume: 111
  start-page: 3657
  year: 2014
  ident: ref_22
  article-title: Ancient insights into uric acid metabolism in primates
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1401037111
– volume: 50
  start-page: 1423
  year: 2012
  ident: ref_36
  article-title: Hypouricemic effect of the methanol extract from Prunus mume fruit in mice
  publication-title: Pharm. Biol.
  doi: 10.3109/13880209.2012.683115
– volume: 23
  start-page: 744
  year: 2020
  ident: ref_38
  article-title: Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells
  publication-title: Iran. J. Basic Med. Sci.
– volume: 59
  start-page: 2066
  year: 2015
  ident: ref_21
  article-title: Modulation of gut microbiota in rats fed high-fat diets by processing whole-grain barley to barley malt
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201500187
– volume: 6
  start-page: 20602
  year: 2016
  ident: ref_8
  article-title: Intestinal Microbiota Distinguish Gout Patients from Healthy Humans
  publication-title: Sci. Rep.
  doi: 10.1038/srep20602
– volume: 43
  start-page: 1139
  year: 2019
  ident: ref_43
  article-title: Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis
  publication-title: Int. J. Mol. Med.
– volume: 111
  start-page: 3763
  year: 2014
  ident: ref_23
  article-title: Evolutionary history and metabolic insights of ancient mammalian uricases
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1320393111
– volume: 46
  start-page: 167
  year: 2018
  ident: ref_2
  article-title: Biochemical and dietary factors of uric acid stone formation
  publication-title: Urolithiasis
  doi: 10.1007/s00240-017-0965-2
– volume: 11
  start-page: 524236
  year: 2020
  ident: ref_34
  article-title: Association of Hyperuricemia With Immune Disorders and Intestinal Barrier Dysfunction
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2020.524236
– volume: 34
  start-page: 5061
  year: 2020
  ident: ref_45
  article-title: Protective effects of tuna meat oligopeptides (TMOP) supplementation on hyperuricemia and associated renal inflammation mediated by gut microbiota
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
– volume: 38
  start-page: 623
  year: 2019
  ident: ref_12
  article-title: Antiobesity and Uric Acid-Lowering Effect of Lactobacillus plantarum GKM3 in High-Fat-Diet-Induced Obese Rats
  publication-title: J. Am. Coll. Nutr.
  doi: 10.1080/07315724.2019.1571454
– volume: 60
  start-page: 2217
  year: 2021
  ident: ref_46
  article-title: Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in Uox-knockout mice
  publication-title: Eur. J. Nutr.
  doi: 10.1007/s00394-020-02414-x
– volume: 56
  start-page: 679
  year: 2017
  ident: ref_6
  article-title: Drug-induced hyperuricaemia and gout
  publication-title: Rheumatology
– volume: 25
  start-page: 506
  year: 2017
  ident: ref_37
  article-title: The Role of the Immune System in Metabolic Health and Disease
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2017.02.006
– volume: 26
  start-page: 186
  year: 2014
  ident: ref_4
  article-title: Definition of hyperuricemia and gouty conditions
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/BOR.0000000000000028
– volume: 77
  start-page: 323
  year: 2015
  ident: ref_3
  article-title: The molecular physiology of uric acid homeostasis
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-021113-170343
– volume: 9
  start-page: 2233
  year: 2018
  ident: ref_40
  article-title: Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2018.02233
– volume: 2016
  start-page: 7390504
  year: 2016
  ident: ref_26
  article-title: Natural Products Improving Hyperuricemia with Hepatorenal Dual Effects
  publication-title: Evid. Based Complement. Altern. Med. Ecam
  doi: 10.1155/2016/7390504
– volume: 72
  start-page: 4111
  year: 2015
  ident: ref_31
  article-title: Macrophage polarization in pathology
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-015-1995-y
– volume: 36
  start-page: 223
  year: 2020
  ident: ref_28
  article-title: The optimization and assessment of the method for inducing hyperuricemia in rats
  publication-title: Chin. J. Appl. Physiol.
– volume: 10
  start-page: CD010156
  year: 2014
  ident: ref_11
  article-title: Dietary supplements for chronic gout
  publication-title: Cochrane. Database Syst. Rev.
– volume: 2019
  start-page: 3480718
  year: 2019
  ident: ref_7
  article-title: Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions
  publication-title: J. Nutr. Metab.
  doi: 10.1155/2019/3480718
– volume: 29
  start-page: 1335
  year: 2019
  ident: ref_13
  article-title: Role of Probiotics in Human Gut Microbiome-Associated Diseases
  publication-title: J. Microbiol. Biotechnol.
  doi: 10.4014/jmb.1906.06064
– ident: ref_35
  doi: 10.1371/journal.pone.0202572
– volume: 52
  start-page: 1442
  year: 2003
  ident: ref_47
  article-title: Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts
  publication-title: Gut
  doi: 10.1136/gut.52.10.1442
– ident: ref_10
  doi: 10.1371/journal.pone.0030456
– volume: 28
  start-page: 115
  year: 2012
  ident: ref_32
  article-title: Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats
  publication-title: Lab. Anim. Res.
  doi: 10.5625/lar.2012.28.2.115
– volume: 58
  start-page: 87
  year: 2006
  ident: ref_25
  article-title: Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol
  publication-title: Pharmacol. Rev.
  doi: 10.1124/pr.58.1.6
– volume: 26
  start-page: 29
  year: 2013
  ident: ref_29
  article-title: Change trends of organ weight background data in sprague dawley rats at different ages
  publication-title: J. Toxicol. Pathol.
  doi: 10.1293/tox.26.29
– volume: 60
  start-page: 791
  year: 1996
  ident: ref_30
  article-title: Food intake and body weight in rats with daily food-availability restrictions
  publication-title: Physiol. Behav.
  doi: 10.1016/0031-9384(96)00161-8
– volume: 48
  start-page: 186
  year: 2015
  ident: ref_19
  article-title: Altered fecal microbiota composition in patients with major depressive disorder
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2015.03.016
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Snippet Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus...
Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that can improve...
Hyperuricemia (HC) is one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus...
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SubjectTerms Animals
Bacteria
Chronic illnesses
Diet
Dietary Supplements
Disease
Feces
Hyperuricemia - chemically induced
Hyperuricemia - prevention & control
Kidneys
Lactobacillus plantarum - physiology
Male
Metabolism
Microbiota
Potassium
Probiotics
Rats
Rats, Sprague-Dawley
Rheumatism
Triglycerides
Uric Acid
Urine
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Title Supplementation of Lactobacillus plantarum (TCI227) Prevented Potassium-Oxonate-Induced Hyperuricemia in Rats
URI https://www.ncbi.nlm.nih.gov/pubmed/36432519
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Volume 14
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