Disorders of IGFs and IGF-1R signaling pathways

• Published in: Molecular and cellular endocrinology Vol. 518; p. 111035
• Main Authors: Forbes, Briony E., Blyth, Andrew J., Wit, Jan M.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2020
• Subjects: genomics; growth and development; homozygosity; humans; IGF-1R; IGF-I; IGF-I deficiency; IGF-II; IGFBPs; insulin-like growth factor I receptor; ligands; metabolism; placenta; SHORT syndrome; somatotropin; IGF-I; SHORT syndrome; IGF-1R; IGFBPs; IGF-I deficiency; IGF-II

The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitud...