PROX1-mediated epigenetic silencing of SIRT3 contributes to proliferation and glucose metabolism in colorectal cancer

• Published in: International journal of biological sciences Vol. 19; no. 1; pp. 50 - 65
• Main Authors: Gan, Lu, Li, Qingguo, Nie, Wei, Zhang, Yi, Jiang, Hesheng, Tan, Cong, Zhang, Long, Zhang, Jieyun, Li, Qian, Hou, Pengcong, Yuan, Yitao, Sun, Xun, Liu, Dongmei, Sheng, Weiqi, Liu, Tianshu, Xu, Midie, Guo, Weijian
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 2023; Ivyspring International Publisher
• Subjects: Cancer; Cancer therapies; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Chemotherapy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - metabolism; Consortia; Epigenesis, Genetic - genetics; Epigenetics; Experiments; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Genomes; Glucose; Glucose - metabolism; Glycolysis; Homeobox; Human subjects; Humans; Kinases; Medical prognosis; Metabolism; Metastasis; Online data bases; Prospero protein; Protein expression; Proteins; R&D; Research & development; Research Paper; Sirtuin 3 - metabolism; Tomography; Transcription Factors - metabolism; Tumors; United States > US; China; colorectal cancer; PROX1; aerobic glycolysis; prognosis; EZH2; SIRT3

Prospero-related homeobox 1 (PROX1) is a homeobox transcription factor known to promote malignant transformation and stemness in human colorectal cancer (CRC). However, the biological function of PROX1 in metabolic rearrangement in CRC remains unclear. Here, we aimed to uncover the relationship betw...