Mechanism of ribosome translation through mRNA secondary structures

• Published in: International journal of biological sciences Vol. 13; no. 6; pp. 712 - 722
• Main Authors: Xie, Ping, Chen, Hong
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2017; Ivyspring International Publisher
• Subjects: Humans; Macromolecules; mRNA; Nucleic Acid Conformation; Protein Structure, Secondary; Review; Ribonucleic acid; Ribosomes - metabolism; RNA; RNA, Messenger - chemistry; RNA, Messenger - metabolism; RNA, Transfer - chemistry; RNA, Transfer - metabolism; Translation; Unwinding; molecular machine; mRNA; translocation; tRNA; Protein synthesis; ribosomal rotation

A ribosome is a macromolecular machine that is responsible for translating the genetic codes in messenger RNA (mRNA) into polypeptide chains. It has been determined that besides translating through the single-stranded region, the ribosome can also translate through the duplex region of mRNA by unwin...