SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models

• Published in: Neuroscience letters Vol. 559; pp. 174 - 178
• Main Authors: Ono, Yoko, Tanaka, Hirotaka, Takata, Masafumi, Nagahara, Yuki, Noda, Yasuhiro, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Hozumi, Isao, Hara, Hideaki
• Format: Journal Article
• Language: English
• Published: Ireland 24.01.2014
• Subjects: Amyotrophic Lateral Sclerosis - drug therapy; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - pathology; Animals; Cell Line; Disease Models, Animal; Female; Humans; Mice; Mice, Transgenic; Motor Neurons - drug effects; Motor Neurons - pathology; Neural Inhibition - genetics; Piperazines - pharmacology; Piperazines - therapeutic use; Receptors, sigma - agonists; Receptors, sigma - physiology; Sigma-1 Receptor; Extracellular signal-regulated kinase (ERK) 1/2; Sigma-1 receptor; Akt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Recently, it has been reported that a mutation in the sigma-1 receptor causes juvenile ALS. Therefore, the function of the sigma-1 receptor may be important in the pathology of ALS. In the present study, we investigated...