Resveratrol reduces RVLM neuron activity via activating the AMPK/Sirt3 pathway in stress-induced hypertension

• Published in: The Journal of biological chemistry Vol. 301; no. 4; p. 108394
• Main Authors: Wang, Lin-Ping, Liu, Tian-Feng, Dai, Teng-Teng, Deng, Xin, Tong, Lei, Zeng, Qiang-Cheng, He, Qing, Ren, Zhang-Yan, Zhang, Hai-Li, Liu, Hai-Sheng, Li, Yan-Fang, Li, Wen-Zhi, Zhang, Shuai, Du, Dong-Shu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2025; American Society for Biochemistry and Molecular Biology
• Subjects: AMP-Activated Protein Kinases - metabolism; Animals; Antioxidants - pharmacology; apoptosis; Apoptosis - drug effects; ferroptosis; Hypertension - drug therapy; Hypertension - etiology; Hypertension - metabolism; Hypertension - pathology; Male; Medulla Oblongata - drug effects; Medulla Oblongata - metabolism; Medulla Oblongata - pathology; Mitochondria - drug effects; Mitochondria - metabolism; mitochondrial oxidative stress; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Oxidative Stress - drug effects; Rats; Rats, Sprague-Dawley; reactive oxygen species; Resveratrol - pharmacology; RVLM; Signal Transduction - drug effects; Sirtuin 3 - genetics; Sirtuin 3 - metabolism; Sirtuins; DHE; Cyt-cyto C; ferroptosis; mitochondrial oxidative stress; apoptosis; HR; MDA; BP; Com.C; RSNA; reactive oxygen species; CCK-8; cDNA; RVLM; DCF; qRT-PCR; SOD; MMP; SIH; RSV; TH; AAV; CAT; NE; ROS; TEM

Neuronal hyperexcitability in the rostral ventrolateral medulla (RVLM), driven by oxidative stress, plays a crucial role in stress-induced hypertension (SIH). While resveratrol (RSV) is known for its antioxidant properties, its effects on RVLM neurons in SIH remain unclear. We investigated this usin...