Long-Term Redistribution of Peripheral Lymphocyte Subpopulations after Switching from Calcineurin to mTOR Inhibitors in Kidney Transplant Recipients

• Published in: Journal of clinical medicine Vol. 9; no. 4; p. 1088
• Main Authors: Llinàs-Mallol, Laura, Redondo-Pachón, Dolores, Raïch-Regué, Dàlia, Pérez-Sáez, María José, Yélamos, José, Duran, Xavier, Faura, Anna, López-Botet, Miguel, Pascual, Julio, Crespo, Marta
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.04.2020; MDPI
• Subjects: Antibodies; Antigens; Clinical medicine; Creatinine; Kidney diseases; Kidney transplants; Kinases; Lymphocytes; Statistical analysis; Steroids; United States > US; donor-specific antibody; NK cells; transitional B cells; T regulatory cells; immunophenotype; kidney transplantation; mTOR inhibitors

Classical immunosuppression based on steroids, calcineurin inhibitors, and mycophenolate results in several unwanted effects and unsatisfactory long-term outcomes in kidney transplantation (KT). New immunosuppressors search for fewer adverse events and increased graft survival but may have a distinc...