IMPA2 Downregulation Enhances mTORC1 Activity and Restrains Autophagy Initiation in Metastatic Clear Cell Renal Cell Carcinoma

• Published in: Journal of clinical medicine Vol. 9; no. 4; p. 956
• Main Authors: Kuei, Chia-Hao, Lin, Hui-Yu, Lee, Hsun-Hua, Lin, Che-Hsuan, Zheng, Jing-Quan, Chen, Kuan-Chou, Lin, Yuan-Feng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.03.2020; MDPI
• Subjects: Autophagy; Clinical medicine; Enzymes; Genes; Kidney cancer; Kinases; Laboratory animals; Membranes; Metastasis; Penicillin; Plasmids; Proteins; United States > US; Taiwan; mTOR; renal cell carcinoma; autophagy; IMPA2; metastasis

Although mTOR inhibitors have been approved as first-line therapy for treating metastatic clear cell renal cell carcinoma (ccRCC), the lack of useful markers reduces their therapeutic effectiveness. The objective of this study was to estimate if inositol monophosphatase 2 (IMPA2) downregulation refe...