SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 69; no. 9; pp. 1875 - 1886
• Main Authors: Obukhov, Alexander G., Stevens, Bruce R., Prasad, Ram, Li Calzi, Sergio, Boulton, Michael E., Raizada, Mohan K., Oudit, Gavin Y., Grant, Maria B.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.09.2020
• Subjects: ACE2; Angiotensin AT1 receptors; Angiotensin II; Angiotensin II - metabolism; Angiotensin-Converting Enzyme 2; Betacoronavirus - metabolism; Bone marrow; Bone Marrow - metabolism; Clinical deterioration; Clinical outcomes; Coronaviridae; Coronavirus Infections - metabolism; Coronavirus Infections - mortality; Coronavirus Infections - physiopathology; Coronaviruses; COVID-19; Diabetes; Diabetes mellitus; Diabetes Mellitus - metabolism; Digestive system; Epithelial cells; Epithelium; Gastrointestinal tract; Humans; Intestinal Mucosa - metabolism; Intestine; Morbidity; Mortality; Pandemics; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - metabolism; Pneumonia, Viral - mortality; Pneumonia, Viral - physiopathology; Receptor, Angiotensin, Type 1 - metabolism; Renin; Renin-Angiotensin System; s in Diabetes; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Spike glycoprotein

Individuals with diabetes suffering from coronavirus disease 2019 (COVID-19) exhibit increased morbidity and mortality compared with individuals without diabetes. In this Perspective, we critically evaluate and argue that this is due to a dysregulated renin-angiotensin system (RAS). Previously, we h...