Pulmonary concentrations of dirithromycin and erythromycin during acute exacerbation of mild chronic obstructive pulmonary disease

• Published in: The European respiratory journal Vol. 10; no. 1; pp. 98 - 103
• Main Authors: Matera, MG, Tufano, MA, Polverino, M, Rossi, F, Cazzola, M
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.01.1997; Maney
• Subjects: Administration, Oral; Anti-Bacterial Agents - analysis; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - therapeutic use; Biological and medical sciences; Bronchi - metabolism; Bronchoalveolar Lavage Fluid - chemistry; Drug Administration Schedule; Epithelium - metabolism; Erythromycin - analogs & derivatives; Erythromycin - analysis; Erythromycin - blood; Erythromycin - therapeutic use; Exudates and Transudates - chemistry; Female; Follow-Up Studies; Humans; Lung - metabolism; Lung Diseases, Obstructive - drug therapy; Lung Diseases, Obstructive - metabolism; Macrolides; Male; Medical sciences; Middle Aged; Mucous Membrane - metabolism; Patient Compliance; Pharmacology. Drug treatments; Respiratory system; Time Factors; Human; Lung disease; Drug combination; Respiratory disease; Lung; Dirithromycin; Exploration; Bioavailability; Erythromycin; Macrolide; Antibiotic; Chemotherapy; Chronic; Treatment; Bronchus disease; Obstructive pulmonary disease; Pharmacokinetics
• ISSN: 0903-1936; 1399-3003
• DOI: 10.1183/09031936.97.10010098

We compared the concentrations of dirithromycin and erythromycin at steady state in serum and the intrapulmonary region in patients suffering from acute exacerbation of mild chronic obstructive pulmonary disease. Twenty patients received dirithromycin, 500 mg given orally once daily for five consecu...