Screening diagnostic candidates from Leishmania infantum proteins for human visceral leishmaniasis using an immunoproteomics approach

• Published in: Parasitology Vol. 146; no. 11; pp. 1467 - 1476
• Main Authors: Lage, Daniela P., Ludolf, Fernanda, Silveira, Patrícia C., Machado, Amanda S., Ramos, Fernanda F., Dias, Daniel S., Ribeiro, Patrícia A. F., Costa, Lourena E., Vale, Danniele L., Tavares, Grasiele S. V., Martins, Vívian T., Chávez-Fumagalli, Miguel A., Caligiorne, Rachel B., Chaves, Ana T., Gonçalves, Denise U., Rocha, Manoel O. C., Duarte, Mariana C., Coelho, Eduardo A. F.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.09.2019
• Subjects: Adult; Amastigotes; Antigens; Antigens, Protozoan - immunology; Bone marrow; Chagas disease; cross reaction; Cross-reactivity; diagnostic techniques; Endonuclease; Enzyme-linked immunosorbent assay; enzymes; Epidemiology; Female; GTP-binding protein; Health care; human diseases; Humans; Immunology; Leishmania infantum; Leishmania infantum - physiology; Leishmaniasis, Visceral - immunology; Male; Middle Aged; Parasites; Parasitic diseases; Patients; Promastigotes; Proteins; Proteomics; Protozoan Proteins - immunology; screening; serodiagnosis; Serology; toxicity; Tropical diseases; Vaccines; Vector-borne diseases; Visceral leishmaniasis; United States > US; recombinant proteins; serodiagnosis; immunoproteomics; Leishmania infantum; visceral leishmaniasis; Humans

There is no suitable vaccine against human visceral leishmaniasis (VL) and available drugs are toxic and/or present high cost. In this context, diagnostic tools should be improved for clinical management and epidemiological evaluation of disease. However, the variable sensitivity and/or specificity...